Review ArticlePercutaneous Radiofrequency Ablation of Hepatic Colorectal Metastases Technique, Indications, Results, and New PromisesLencioni, Riccardo MD; Crocetti, Laura MD; Cioni, Dania MD; Della Pina, Clotilde MD; Bartolozzi, Carlo MDAuthor Information From the Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplants, and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy. Received February 2, 2004 and accepted for publication, after revision, July 11, 2004. Reprints: Prof. Dr. Riccardo Lencioni, Division of Diagnostic and Interventional Radiology, University of Pisa, Via Roma 67, IT-56126 Pisa, Italy. E-mail: [email protected] Investigative Radiology: November 2004 - Volume 39 - Issue 11 - p 689-697 Buy Abstract Surgical resection is the standard of care for colorectal metastases isolated to the liver. However, only 10–25% of the patients are eligible for resection because of extent and location of the disease in the liver or concurrent medical conditions. Image-guided radiofrequency (RF) ablation is a minimally invasive technique that is emerging as a viable alternate treatment of nonsurgical patients with limited hepatic metastatic disease. Several series have shown that RF ablation can result in complete tumor eradication in properly selected candidates and have provided indirect evidence that the treatment improves survival. In a recent multicenter trial including 423 patients, overall survival of RF-ablation treated patients reached 47% at 3 years and 24% at 5 years. RF ablation technology is undergoing continuous improvement, and its clinical application has been successfully expanded to the treatment of colorectal metastases to the lung. Randomized trials comparing RF ablation with either surgical resection or chemotherapy protocols, however, are still missing. In this article, we review technique, indications, clinical results, and future prospects of RF ablation in the therapeutic management of metastatic colorectal cancer patients. © 2004 Lippincott Williams & Wilkins, Inc.