Original ArticleAssessment of Sequential Enhancement Patterns of Focal Nodular Hyperplasia and Hepatocellular Carcinoma on Mangafodipir Trisodium Enhanced MR ImagingSavellano, Dagmar Högemann MD*; Köstler, Herbert PhD†; Baus, Stefan MD*; Mössinger, Meike MD*; Gratz, Klaus Friedrich MD‡; Weimann, Arved MD§; Galanski, Michael MD*Author Information From the *Abteilung für Diagnostische Radiologie, Medizinische Hochschule Hannover, Hannover, Germany; †Institut für Röntgendiagnostik, Universität Würzburg, Würzburg, Germany; ‡Klinik für Nuklearmedizin, Medizinische Hochschule Hannover, Hannover, Germany; and §Klinik für Allgemein- und Visceralchirurgie, Städtisches Klinikum St. Georg, Leipzig, Germany. Received September 30, 2003 and accepted for publication, after revision, January 17, 2004. Reprints: Dr. Dagmar H. Savellano, Diagnostische Radiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; E-mail: [email protected] Investigative Radiology: May 2004 - Volume 39 - Issue 5 - p 305-312 doi: 10.1097/01.rli.0000120372.55482.eb Buy Metrics Abstract Rationale and Objectives: Sequential contrast changes of mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance imaging (MRI) were evaluated in the differentiation of focal nodular hyperplasias (FNH) and hepatocellular carcinomas (HCC). Methods: Patients with FNH (n = 16) or HCC (n = 12) underwent MRI: T2-weighted fast spin echo before and T1-weighted gradient echo before and 1, 4, 14, and 22 hours after 5 μmol/kg Mn-DPDP. Homogeneity of enhancement and delineation of fibrous scars of FNHs were assessed qualitatively. Lesion-to-liver contrast changes of FNHs and HCCs were compared quantitatively (Mann-Whitney U). Results: Mn-DPDP improved detection of characteristic scars of FNHs from 50% before to 90% after contrast agent. Apart from fibrous tissue enhancement of FNHs was mostly homogeneous (90%). Time-dependent contrast changes were up to 20 times higher (after 4 hours) for FNHs than HCCs (P < 0.0001). Conclusions: Mn-DPDP-enhanced MRI helps to delineate characteristic morphologic features of FNHs and can provide quantitative data differentiating FNH and HCC. © 2004 Lippincott Williams & Wilkins, Inc.