Original ArticlesHigh-Resolution Three-Dimensional Contrast-Enhanced Blood Oxygenation Level-Dependent Magnetic Resonance Venography of Brain Tumors at 3 Tesla: First Clinical Experience and Comparison with 1.5 TeslaBarth, Markus PhD*; Nöbauer-Huhmann, Iris-Melanie MD*; Reichenbach, Jürgen R. PhD†; Mlynárik, Vladimir PhD*; Schöggl, Andreas MD‡; Matula, Christian MD‡; Trattnig, Siegfried MD* Author Information *Department of Radiology and ‡Department of Neurosurgery, University and General Hospital Vienna, Austria; and †Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University, Jena, Germany. Received October 12, 2002, and accepted for publication, after revision, February 25, 2002. Reprints: Dr. Markus Barth, Univ. Klinik f. Radiodiagnostik, Universitaet und AKH Wien, Waehringer Guertel 18-20, A-1090 Vienna. E-mail: [email protected] This study was funded by research grant no.1971 (Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien) and by the Nycomed Amersham Research Fellowship Grant (to J.R.R.) of the ECR 2002 Research and Education Fund. Investigative Radiology: July 2003 - Volume 38 - Issue 7 - p 409-414 doi: 10.1097/01.RLI.0000069790.89435.e7 Buy Metrics Abstract Rationale and Objectives To evaluate the clinical potential of high-resolution 3D contrast-enhanced blood oxygenation level-dependent MR-Venography (CE-MRV) for primary brain tumors and metastases at 3 Tesla (T) in comparison to 1.5 T. Methods Eighteen patients with brain tumors were examined using CE-MRV after application of a standard dose of MRI contrast agent (0.1 mmol/kg gadodiamide). CE-MRV is based on a high-resolution 3D flow-compensated gradient-echo sequence with long echo times that uses the contrast-enhanced blood oxygenation level-dependent effect. This technique was performed using the same volume coverage and acquisition time at both field strengths after performing standard imaging sequences. Results The higher spatial resolution of CE-MRV at 3 T showed more details within and around tumors than at 1.5 T. Visibility was enhanced by stronger susceptibility weighting and higher intrinsic signal-to-noise at 3 T. Compared with standard imaging protocols, additional information characterized as tubular and nontubular hypointense structures were found within or around lesions on CE-MRV images. Conclusions Acquisition of CE-MRV data at 3 T enables spatial resolution to be increased within the same measurement time and with the same volume coverage compared with 1.5 T, thus providing more detailed information. The method may also show the potential to estimate oxygen supply of tumors, especially at high field strengths. © 2003 Lippincott Williams & Wilkins, Inc.