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Contrast Medium–Induced Pulmonary Vascular Hyperpermeability Is Aggravated in a Rat Climacterium Model

TOMINAGA, KOJI MS; KATAOKA, YASUFUMI PhD; SENDO, TOSHIAKI PhD; FURUTA, WAKAKO BS; NIIZEKI, MIDORI BS; OISHI, AND RYOZO PhD

Original Investigations
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Tominaga K, Kataoka Y, Sendo T, et al. Contrast medium–induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model. Invest Radiol 2001;36:131–135.

rationale and objectives.  To test whether climacterium influences adverse pulmonary reactions to contrast media, the authors investigated the effect of ioxaglate on pulmonary vascular permeability in ovariectomized rats as a climacterium model.

methods. From 7 days after surgery, ovariectomized rats were treated with estradiol valerate or vehicle once per week for 3 weeks. At 28 days after surgery, ioxaglate, an ionic contrast medium, was intravenously injected at 1.5 mL/min in rats. Pulmonary vascular permeability was evaluated by measuring the amount of Evans blue dye in the lung tissue.

results. Ioxaglate dose-dependently increased pulmonary vascular permeability in sham-operated and ovariectomized rats. Ovariectomized rats showed a 2.6-fold increased aggravation of vascular permeability by ioxaglate 4 g I/kg compared with sham-operated rats. Estradiol valerate (0.2–5.0 mg/kg) dose-dependently blocked ioxaglate-increased vascular permeability in ovariectomized rats.

conclusions. These findings suggest that climacterium is included, at least in part, in the risk factors for contrast-induced adverse pulmonary reactions, and this risk is lowered by estrogen replacement therapy.

From the Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Supported in part by Health Sciences Research Grants for Research on Pharmaceutical and Medical Safety from the Ministry of Health and Welfare of Japan.

Reprint requests: Dr. Yasufumi Kataoka, Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; e-mail: ykataoka@st.hosp.kyusyu-u.ac.jp

Received June 5, 2000, and accepted for publication, after revision, October 9, 2000.

© 2001 Lippincott Williams & Wilkins, Inc.