PRASAD, POTTUMARTHI V. PHD*; CANNILLO, JOHN BS*; CHAVEZ, DAVID R. MD*; PINCHASIN, ESTHER S. BS*; DOLAN, ROBERT P. PHD†; WALOVITCH, RICHARD PHD†; EDELMAN, ROBERT R. MD*
From *Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, and †EPIX Medical Inc., Cambridge, Massachusetts.
Received March 5, 1999, and accepted for publication, after revision, May 9, 1999.
Reprint requests: Dr. Pottumarthi V. Prasad, Department of Radiology, MRI, AN-234, Beth Israel Deaconess Medical Center, East Campus, 330 Brookline Avenue, Boston, MA 02215.
Supported in part by a Biomedical Engineering Research grant from the Whitaker Foundation (Prasad).
The authors thank EPIX Medical Inc. (formerly METASYN), Cambridge, Massachusetts, for providing MS-325 and its protein-binding data in pig blood. They also thank Mr. Stephen Gladstone and Dr. Vojkan Suslic for their help in implementing the animal model and Dr. Wei Li for his technical support.
