Original Investigation: PDF OnlySonographic—Histopathologic Correlation on Human Tumor in Nude Mice Treated with Percutaneous Ethanol Injection Therapy and Radiation TherapyFARUTA, MASAYA MD; HASEGAWA, MASATOSHI MD; MITSUHASHI, NORIO MD; YAMAKAWA, MICHITAKA MD; NIIBE, HIDEO MDAuthor Information Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Gunma, Japan. Investigative Radiology: January 1995 - Volume 30 - Issue 1 - p 10-20 Buy Abstract OBJECTIVE To clarify the relation between ultrasonography and histopathologic findings on tumor treated with percutaneous ethanol injection therapy (PEIT) and radiation therapy. MATERIALS AND METHODS Ultrasound–histopathologic correlation was examined in animal models of PEIT and radiation therapy using human tumor xenografts. RESULTS The detectability of intratumoral necrosis was correlated with size, distribution, and histologic features of necrosis. Echogenicity of necrosis induced by PEIT varied: coagulation necrosis with few basophilic degenerated nuclei was hyperechoic to viable tumor and easily recognized 7 to 14 days after PEIT. Necrosis, including abundant basophilic nuclei, showed similar echogenicity to viable tumor and was poorly identified. Six hours after radiation therapy, shrunken cells appeared scattered throughout the tumor, but they were not detected by ultrasound. CONCLUSION To evaluate the effectiveness of a treatment with ultrasound through changes of internal echoes, the pattern of cell death also should be considered, which influences echogenicity of treated tumor tissue. © Lippincott-Raven Publishers.