Original Investigation: PDF OnlyIn Vivo P-31-MR-Spectroscopy of Focal Hepatic Lesions Effectiveness of Tumor Detection in Clinical Practice and Experimental Studies of Surface Coil Characteristics and Localization TechniqueBRINKMANN, GISBERT MD*; MELCHERT, UWE H. MSC*; EMDE, LARS MD*; WOLF, HEIKE MSC†; MUHLE, CLAUS MD*; BROSSMANN, JOACHIM MD*; REUTER, MICHAEL MD*; HELLER, MARTIN MD*Author Information *Department of Diagnostic Radiology, Christian-Albrechts-University of Kiel, Germany † Department of Nuclear Medicine, Christian-Albrechts-University of Kiel, Germany. Investigative Radiology: January 1995 - Volume 30 - Issue 1 - p 56-63 Buy Abstract RATIONALE AND OBJECTIVES The influence of partial tumor sampling in a volume of interest (VOI) on the ratios of phosphorus metabolites was examined by localized phosphorus magnetic resonance spectroscopy (P-31-MRS). Experiments were performed to investigate the characteristics of the surface coil used and precession of spatial localization. METHODS A total of 24 patients with liver metastases and 20 volunteers were studied by P-31-MRS. Patients were divided in two groups: VOI < 50% (n = 8) and VOI > 50% (n = 16) occupied by tumor. For evaluation of the surface coil and localization method (image selected in vivo spectroscopy), phantom studies were performed. RESULTS Superficial focal liver tumors were detectable with a surface coil at a distance within the coil radius. The image selected in vivo spectroscopy permitted the study of phosphorus metabolism in a defined VOI. phosphomonoester/β-adenosine triphosphate and phosphodiester/β-adenosine triphosphate were elevated significantly in spectra of both patient groups. CONCLUSIONS. Detection of small tumor volumes within a VOI filled by less than 50% of the tumor is possible, with results statistically different from that in normal volunteers. © Lippincott-Raven Publishers.