Original Investigations: PDF OnlyEstimation of Glomerular Filtration Rate from Low-Dose Injection of Iohexol and a Single Blood SampleTHOMSEN, HENRIK S. MD, PhD; HVID-JACOBSEN, KELD MD Author Information From the Departments of Diagnostic Radiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark Investigative Radiology: April 1991 - Volume 26 - Issue 4 - p 332-336 Buy Abstract Clearance of a small dose of iohexol (7 g I) was compared with the glomerular filtration rate (GFR) marker 5lCr EDTA in 11 healthy volunteers. The two tracers were injected simultaneously. The plasma concentration of iohexol was measured with x-ray fluorescence technique. Glomerular filtration rate was determined using blood samples drawn three and four hours after injection. An excellent correlation (0.92 < r < 0.97) between iohexol clearance and 5lCr EDTA clearance was found. Glomerular nitration rate can be reliably determined with a low dose of iohexol and a single blood sample obtained three hours after the injection in persons with normal serum creatinine. This new method is a good alternative to the methods using radiopharmaceuticals; it causes no radioactive burden to the patients, increases patient comfort, reduces costs, and requires no special license. © Lippincott-Raven Publishers.
