BENSON DANIEL M. MS; RIFKIN, MATTHEW D. MD; ROSE, JOSEPH L. PhD; GOLDBERG, BARRY B. MDInvestigative Radiology: September-October 1983 Original Investigations: PDF Only Buy Abstract A physical basis was developed for an accurate noninvasive technique to differentiate malignant thyroid tumors from benign lesions based upon a frequency-dependent attenuation model. The research effort utilized RF waveform analysis via a minicomputer based digital processing system. Data collection was performed using a standard clinical B-Mode diagnostic instrument with a transducer specially designed for imaging the thyroid gland. Differences between the frequency spectra of the RF waveforms for benign and malignant pathologies could be demonstrated in accordance with the proposed model. © Lippincott-Raven Publishers.