Review ArticleIs cognition considered in post-stroke upper limb robot-assisted therapy trials? A brief systematic reviewEverard, Gauthier J.a; Ajana, Khawlab; Dehem, Stéphanie B.a,,c; Stoquart, Gaëtan G.a,,c; Edwards, Martin G.b; Lejeune, Thierry M.a,,c Author Information aNeuro Musculo Skeletal Lab (NMSK), Institut de Recherche Expérimentale et Clinique, Secteur des Sciences de la Santé, Université catholique de Louvain, Brussels bPsychological Sciences Research Institute (IPSY), Université catholique de Louvain, Louvain-la-Neuve cService de médecine physique et réadaptation, Cliniques universitaires Saint-Luc, Brussels, Belgium Received 30 April 2020 Accepted 8 May 2020 Correspondence to Thierry M. Lejeune, MD, PhD, Cliniques universitaires Saint Luc, Médecine Physique et Réadaptation, Avenue Hippocrate 10, 1200 Brussels, Belgium, Tel: +32 2 764 90 63; fax: +32 2 764 90 63; e-mail: [email protected] International Journal of Rehabilitation Research: September 2020 - Volume 43 - Issue 3 - p 195-198 doi: 10.1097/MRR.0000000000000420 Buy Metrics Abstract The aim of this systematic review was, first, to determine whether or not individuals with cognitive deficits after stroke were enrolled in trials that investigated upper limb robot-assisted therapy effectiveness, and, second, whether these trials measured cognitive outcomes. We retrieved 6 relevant systematic reviews covering, altogether, 66 articles and 2214 participants. Among these 66 clinical trials, only 10 (15%) enrolled stroke participants with impaired cognition, whereas 50 (76%) excluded those with impaired cognition. The remaining six trials (9%) were classified as unclear as they either excluded individuals unable to understand simple instructions or did not specify if those with cognitive disorders were included. Furthermore, only 5 trials (8%) used cognitive measures as outcomes. This review highlights a lack of consideration for individuals with cognitive impairments in upper limb robotic trials after stroke. However, cognition is important for complex motor relearning processes and should not be ignored. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.