Brief Research ReportsLook at the cognitive deficits in patients with myotonic dystrophy type 1 an exploratory research on the effects of virtual realityMaresca, Giuseppaa; Portaro, Simonaa; Naro, Antoninoa; Scarcella, Ileanaa; Bramanti, Placidoa; Militi, Davidb; Accorinti, Mariaa; De Luca, Rosariaa; Calabrò, Rocco SalvatoreaAuthor Information aIRCCS Centro Neurolesi “Bonino Pulejo”, Messina bStomatodental Center, Messina, Italy Received 16 July 2019 Accepted 8 October 2019 Correspondence to Rocco Salvatore Calabrò, MD, PhD, IRCCS Centro Neurolesi “Bonino-Pulejo”, S.S. 113, Contrada Casazza, 98124 Messina, Italy, Tel: +39 090 60128840; fax: +39 090 60128950; e-mail: email@example.com International Journal of Rehabilitation Research: March 2020 - Volume 43 - Issue 1 - p 90-94 doi: 10.1097/MRR.0000000000000384 Buy Metrics Abstract Myotonic dystrophy type 1 is a neuromuscular disease, characterized by a progressive loss of strength, muscle stiffness, and difficulty in relaxation. Myotonic dystrophy type 1 patients can present several neuropsychological deficits, as well as anxiety and mood disorders. Aim of this study is to evaluate the feasibility and the effect of virtual reality in the cognitive and behavioral recovery of myotonic dystrophy type 1 patients. Eleven patients (8 female and 3 male) underwent a specific cognitive rehabilitation program including a conventional neuropsychological treatment followed by a virtual reality neurorehabilitation training using the Virtual Reality Rehabilitation System (Khymeia, Italy). Virtual reality improved many cognitive domains, including executive function, attention, verbal and visuo-spatial abilities, as well as mood and coping strategies. Due to the high prevalence of neuropsychological symptoms in patients with myotonic dystrophy type 1, cognitive rehabilitation should enter into the framework of these patients to potentially boost cognitive and behavioral function and improve quality of life. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.