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DNA Mismatch Repair in Sporadic and Hereditary Endometrial Cancer

Creator:   Joseph Rabban, MD MPH
Updated:   8/18/2017
Contains:  11 items
Hereditary syndromes associated with endometrial cancer are not common but pathologists have a unique opportunity to contribute to their diagnoses, particularly Lynch syndrome, in patients for whom endometrial cancer is the sentinel presentation. Because Lynch syndrome is an autosomal dominant disease and carries risk for synchronous and metachronous malignancies in several different organ systems, there is great value to an endometrial cancer patient and to her relatives for pathologists to participate in risk assessment for Lynch syndrome. Many advances have been made in identifying morphologic, immunohistochemical and molecular features of Lynch syndrome-associated endometrial cancers though many questions still remain to be answered in terms of practical application in daily diagnostic pathology practice. This collection highlights the body of work in International Journal of Gynecologic Pathology over the last decade that is dedicated to understanding the pathology of Lynch syndrome-associated endometrial cancers and their mimics.

Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome

Watkins, Jaclyn C.; Yang, Eric J.; Muto, Michael G.; More

International Journal of Gynecological Pathology. 36(2):115-127, March 2017.

Molecular Characterization of Endometrial Cancer: A Correlative Study Assessing Microsatellite Instability, MLH1 Hypermethylation, DNA Mismatch Repair Protein Expression, and PTEN, PIK3CA, KRAS, and BRAF Mutation Analysis

Peterson, Lisa M.; Kipp, Benjamin R.; Halling, Kevin C.; More

International Journal of Gynecological Pathology. 31(3):195-205, May 2012.