Verrcous Carcinoma of the Vulva. A Clinicopathologic and Immunohistochemical Study of Five Cases

Abstract

Summary 

The clinicopathologic features of five cases of vemicous carcinoma of the vulva and their staining pattern with antikeratin monoclonal antibodies AE₁ and AE₃ were compared with those of conventional squamous cell carcinoma. Two patients had local recurrences but none died of the tumor. AE₁ and AE₃ antibodies stained the entire epithelial thickness in both vemicous and squamous cell carcinoma, but in the former the positivity was uniform and homogeneous everywhere, while in squamous cell carcinoma the positivity was extremely disorganized and patchy. The pattern of expression of monoclonal antibodies AE₁ and AE₃ confirms that vemicous carcinoma is an extremely well-differentiated squamous neoplasm in contrast to squamous cell carcinoma, which is heterogeneous from a viewpoint of differentiation.