Joseph Rabban, MD MPH
Hereditary syndromes associated with endometrial cancer are not common but pathologists have a unique opportunity to contribute to their diagnoses, particularly Lynch syndrome, in patients for whom endometrial cancer is the sentinel presentation. Because Lynch syndrome is an autosomal dominant disease and carries risk for synchronous and metachronous malignancies in several different organ systems, there is great value to an endometrial cancer patient and to her relatives for pathologists to participate in risk assessment for Lynch syndrome. Many advances have been made in identifying morphologic, immunohistochemical and molecular features of Lynch syndrome-associated endometrial cancers though many questions still remain to be answered in terms of practical application in daily diagnostic pathology practice. This collection highlights the body of work in International Journal of Gynecologic Pathology over the last decade that is dedicated to understanding the pathology of Lynch syndrome-associated endometrial cancers and their mimics.