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Tubulovillous Adenoma of Vagina With Both KRAS and APC Mutations

Case Report

Shuangshoti, Somruetai M.D.; Teerapakpinyo, Chinachote Ph.D.

International Journal of Gynecological Pathology: September 2019 - Volume 38 - Issue 5 - p 498–501
doi: 10.1097/PGP.0000000000000561
Pathology of the Lower Genital Tract: Case Report
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Adenomatous polyps of the vulva and vagina are extremely rare. We report a case of a 74-yr-old women with a tubulovillous adenoma occurring in the vagina, and a second one occurring later in the vulva. Tumor cells in both lesions were CK7, CK20+, CDX-2+, and showed intact mismatch-repair proteins. A G13D (c.38G>A, p.Gly13Asp) mutation in the KRAS gene was identified in both masses. As well, a novel frameshift truncating mutation (c.4320delA, p.Pro1441fsTer32) in the APC gene was detected only in the vaginal mass, ruling out the possibility that the vulvar mass was a local recurrence of the vaginal mass. This is the first identification of KRAS and APC gene mutations in adenomatous polyps involving the female lower genital tract.

Department of Medical Services, Institute of Pathology, Ministry of Public Health (S.S.)

Chulalongkorn GenePRO Center, Research Affairs, Faculty of Medicine, Chulalongkorn University (C.T.), Bangkok, Thailand

Supported by the National Research Council of Thailand Grant under the Research University Network (RUN) Initiative.

The authors declare no conflict of interest.

Address correspondence and reprint requests to Chinachote Teerapakpinyo, PhD, Chulalongkorn GenePRO Center, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. E-mail: chinachote.t@chula.ac.th.

©2019International Society of Gynecological Pathologists