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Papilloma of the Fallopian Tube

A Rare Gynecologic Neoplasm Harboring a BRAF (c.1799T>A) Mutation (V600E)

Wohlschlaeger, Jeremias M.D.; Davidson, Ben M.D.; Worm, Karl Ph.D.; Feist, Henning M.D.; Peters, Jochen M.D.; Hager, Thomas M.D.; Schmid, Kurt W. M.D.; Ostertag, Horst M.D.

International Journal of Gynecological Pathology: September 2019 - Volume 38 - Issue 5 - p 459–463
doi: 10.1097/PGP.0000000000000526
Pathology of the Upper Genital Tract: Case Reports
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Papillomas of the fallopian tube are exceedingly rare benign tumors, and only very few cases have been reported in the literature. Clinically, they may present as a mass lesion or occur without symptoms. Histomorphologically, they are papillary tumors covered by nonatypical epithelium with occasional ciliated or goblet cells growing in the lumen, and they are most frequently located in the infundibular region of the fallopian tube. They require a number of differential diagnostic evaluations and can be mistaken for either other benign tumors or malignant neoplasms. Because of their rare occurrence, molecular data about this entity have been lacking so far. Herein, a case of a papilloma with a BRAF (c.1799T>A) mutation (V600E) in a 45-yr-old woman with tumor-like dilation of the fallopian tube is presented.

Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Essen (J.W., K.W., T.H., K.W.S)

Institute of Pathology (J.W., H.F., J.P.)

Department of Gynecology and Obstetrics (H.O.), Lutheran Diakonissen-Hospital Flensburg, Flensburg, Germany

Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway (B.D.)

The authors declare no conflict of interest.

Address correspondence and reprint requests to Jeremias Wohlschlaeger, MD, Institute of Pathology, Ev.-luth. Lutheran Diakonissen-Hospital Flensburg, Knuthstrasse 1, Flensburg 24939, Germany. E-mails: wohlschlaegerje@diako.de, jeremias.wohlschlaeger@uk-essen.de.

©2019International Society of Gynecological Pathologists