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Acute Pancreatitis Caused by Isolated Pancreatic Metastasis From Uterine Choriocarcinoma

Muktesh, Gaurav M.B.B.S., M.D., D.M.; Mitra, Suvradeep M.B.B.S., M.D., D.M.; Sinha, Saroj K. M.B.B.S., M.D., D.M.; Dhaka, Narendra M.B.B.S., M.D., D.M.; Saikia, Uma N. M.B.B.S., M.D.; Sarma, Phulen M.B.B.S., M.D., D.M.; Gulati, Ajay M.B.B.S., M.D.; Samanta, Jayanta M.B.B.S., M.D., D.M.; Kochhar, Rakesh M.B.B.S., M.D., D.M.

International Journal of Gynecological Pathology: September 2019 - Volume 38 - Issue 5 - p 430–434
doi: 10.1097/PGP.0000000000000532
Pathology of the Corpus: Case Reports

Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. However, isolated pancreatic metastasis is an extremely rare occurrence and has not been documented in the English literature to the best of our knowledge. The metastatic deposits in the index case led to widespread hemorrhage and necrosis of the pancreatic parenchyma, causing severe acute pancreatitis. The patient succumbed to her illness before chemotherapy was administered. Thus, we present an autopsy case of a uterine choriocarcinoma with isolated pancreatic metastasis presenting as severe acute pancreatitis in a 27-yr-old woman following a molar pregnancy.

Departments of Gastroenterology (G.M., S.K.S., N.D., J.S., R.K.)

Histopathology (S.M., U.N.S.)

Pharmacology (P.S.)

Radiodiagnosis and Imaging (A.G.), Post Graduate Institute of Medical Education and Research, Chandigarh, India

The authors declare no conflict of interest.

Address correspondence and reprint requests to Saroj K. Sinha, MBBS, MD, DM, Department of Gastroenterology, Nehru Hospital, F Block, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail:

©2019International Society of Gynecological Pathologists