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Wilms Tumor of the Uterus

Pinto, Andre, M.D.; Huang, Marilyn, M.D., M.S.; Castillo, Rosa P., M.D.; Schlumbrecht, Matthew P., M.D., M.P.H.

International Journal of Gynecological Pathology: July 2019 - Volume 38 - Issue 4 - p 335–339
doi: 10.1097/PGP.0000000000000500

Wilms tumor (WT) is an uncommon malignant neoplasm that occurs predominantly in the kidney of pediatric patients; its extrarenal counterpart is exceedingly rare. We present the case of an adult female diagnosed with uterine WT. Following hysterectomy due to a uterine mass, histopathologic examination demonstrated a triphasic malignancy composed of epithelial, stromal, and blastemal elements. The characteristic morphologic features, which were supported by immunohistochemical analysis, were diagnostic of WT of the uterus. A summary of the main clinicopathologic parameters, along with a review of all previously reported cases, are described.

Department of Pathology (A.P.)

Obstetrics and Gynecology, Division of Gynecology Oncology (M.H., M.P.S.)

Radiology (R.P.C.), University of Miami Miller School of Medicine, Miami, Florida

The authors declare no conflict of interest.

Address correspondence and reprint requests to Andre Pinto, MD, Department of Pathology, University of Miami Miller School of Medicine, 1611 NW 12th Avenue, Holtz 2145, Miami, FL 33136. E-mail:

©2019International Society of Gynecological Pathologists