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Coexistence of BRAF V600E and TERT Promoter Mutations in Low-grade Serous Carcinoma of Ovary Recurring as Carcinosarcoma in a Lymph Node

Report of a Case

Tavallaee, Mahkam, M.D., M.P.H.; Steiner, David F., M.D., Ph.D.; Zehnder, James L., M.D.; Folkins, Ann K., M.D.; Karam, Amer K., M.D.

International Journal of Gynecological Pathology: July 2019 - Volume 38 - Issue 4 - p 386–392
doi: 10.1097/PGP.0000000000000507

Low-grade serous carcinomas only rarely coexist with or progress to high-grade tumors. We present a case of low-grade serous carcinoma with transformation to carcinosarcoma on recurrence in the lymph node. Identical BRAF V600E and telomerase reverse transcriptase promoter mutations were identified in both the original and recurrent tumor. Given that telomerase reverse transcriptase promotor mutations are thought to play a role in progression of other tumor types, the function of telomerase reverse transcriptase mutations in BRAF mutated low-grade serous carcinoma deserves investigation.

Department of Pathology (M.T., D.F.S., J.L.Z., A.K.F.)

Department of Obstetrics and Gynecology (A.K.K.)

Department of Medicine (J.L.Z.), Stanford University School of Medicine, Stanford

Department of Obstetrics and Gynecology, UCSF Fresno, Fresno (M.T.), California

The authors declare no conflict of interest.

Address correspondence and reprint requests to Mahkam Tavallaee, MD, MPH, Department of Pathology, Stanford Hospital, 300 Pasteur Dr, Palo Alto, CA 94304. E-mail:

©2019International Society of Gynecological Pathologists