Low-grade serous carcinomas only rarely coexist with or progress to high-grade tumors. We present a case of low-grade serous carcinoma with transformation to carcinosarcoma on recurrence in the lymph node. Identical BRAF V600E and telomerase reverse transcriptase promoter mutations were identified in both the original and recurrent tumor. Given that telomerase reverse transcriptase promotor mutations are thought to play a role in progression of other tumor types, the function of telomerase reverse transcriptase mutations in BRAF mutated low-grade serous carcinoma deserves investigation.
Department of Pathology (M.T., D.F.S., J.L.Z., A.K.F.)
Department of Obstetrics and Gynecology (A.K.K.)
Department of Medicine (J.L.Z.), Stanford University School of Medicine, Stanford
Department of Obstetrics and Gynecology, UCSF Fresno, Fresno (M.T.), California
The authors declare no conflict of interest.
Address correspondence and reprint requests to Mahkam Tavallaee, MD, MPH, Department of Pathology, Stanford Hospital, 300 Pasteur Dr, Palo Alto, CA 94304. E-mail: email@example.com.