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Mesonephric Adenocarcinoma of the Uterine Corpus

Report of 2 Cases and Review of the Literature

Zhang, Lin, M.D., Ph.D.; Cai, Zhenjian, M.D., Ph.D.; Ambelil, Manju, M.D.; Conyers, Jeffrey, M.D.; Zhu, Hui, M.D., Ph.D.

International Journal of Gynecological Pathology: May 2019 - Volume 38 - Issue 3 - p 224–229
doi: 10.1097/PGP.0000000000000493

Mesonephric adenocarcinoma (MNA) is believed to arise from benign mesonephric remnants or hyperplasia located in the lateral walls of the uterine cervix. They are uncommon in other sites of the gynecologic tract, and exceptionally rare in the uterine corpus. So far, only 30 cases of uterine MNA have been reported in the literature, as a result, the etiology, clinical behavior, choice of treatment, and histogenesis of uterine MNA are still unclear. In this study, we report 2 cases of MNA of uterine corpus. One case involved the inner half of myometrium with endometrial involvement; the second case involved the outer half of myometrium without endometrial involvement. We also reviewed the clinical and pathologic presentations of this rare entity, and discussed the histogenesis of uterine corpus MNA based on recent molecular findings.

University of Texas Health Science Center at Houston, Houston, TX

The authors declare no conflict of interest.

Address correspondence and reprint requests to Hui Zhu, MD, PhD, University of Texas Health Science Center at Houston, 6413 Fannin Street, Houston, TX 77030. E-mail:

©2019International Society of Gynecological Pathologists