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Neuroendocrine Tumors of the Fallopian Tube

Report of a Case Series and Review of the Literature

Grondin, Katherine, MD; Lidang, Marianne, M.D.; Boenelycke, Marie, M.D.; Alvarado-Cabrero, Isabel, M.D.; Herrington, C. Simon, F.R.C.Path.; McCluggage, W. Glenn, F.R.C.Path.

International Journal of Gynecological Pathology: January 2019 - Volume 38 - Issue 1 - p 78–84
doi: 10.1097/PGP.0000000000000458

Primary neuroendocrine tumors of the fallopian tube are extremely rare with a few reported cases of high-grade neuroendocrine carcinoma and a single report of a carcinoid tumor arising in a teratoma. We report 4 cases of probable primary neuroendocrine tumors of the fallopian tube (2 carcinoid tumors/low-grade neuroendocrine tumors and 2 high-grade neuroendocrine carcinomas) in patients aged 49 to 71. These represent the first reported cases of primary tubal carcinoid tumor unassociated with a teratoma. We review the published literature regarding primary neuroendocrine tumors of the fallopian tube and speculate on the possible histogenesis of these neoplasms.

Pathology Department, L'Hôtel-Dieu de Québec, Centre Hospitalier Universitaire de Québec, Laval University, Quebec City, QC, Canada (K.G.)

Pathology Department, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark (M.L., M.B.)

Pathology Department, del Hospital de Oncología, Mexico City, Mexico (I.A.-C.)

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh Division of Pathology, Edinburgh, United Kingdom (C.S.H.)

Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom (W.G.M.)

The authors declare no conflict of interest.

Address correspondence and reprint requests to W. Glenn McCluggage, FRCPath, Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BA, United Kingdom.E-mail:

©2019International Society of Gynecological Pathologists