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Ganglioneuroblastoma Arising in an Ovarian Dermoid Cyst

First Report in the Literature

Rajendran, Simon, M.D.; Jensen, Debra, M.D.; McCluggage, W. Glenn, F.R.CPath.

International Journal of Gynecological Pathology: January 2019 - Volume 38 - Issue 1 - p 103–107
doi: 10.1097/PGP.0000000000000455

The development of a somatic neoplasm within an ovarian dermoid cyst (mature cystic teratoma) is a rare, but well described, phenomenon which occurs in approximately 1% of all cases. Any of the tissue components of a dermoid cyst has the potential to undergo neoplastic transformation with carcinoid tumors and squamous cell carcinomas being among the most common neoplasms. We report a case of a ganglioneuroblastoma arising within an ovarian dermoid cyst, an association which, as far as we are aware, has not been described previously.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom (S.R., W.G.M.)

Douglass Hanly Moir Pathology, Sydney, New South Wales, Australia (D.J.)

The authors declare no conflict of interest.

Address correspondence and reprint requests to W. Glenn McCluggage, FRCPath, Department of Pathology, Royal Group of Hospitals, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland, United Kingdom. E-mail:

©2019International Society of Gynecological Pathologists