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Skeletal Muscle Metastases from Squamous Cell Carcinoma of the Cervix

Report of Two Cases With Literature Review

Skenderi, Faruk M.D., M.Sc.; Chikha, Adisa M.D.; Ibisevic, Nermina M.D.; Tatarevic-Suko, Aida M.D.; Kantardzic, Nermina M.D.; Vranic, Semir M.D., Ph.D.

International Journal of Gynecological Pathology: January 2017 - Volume 36 - Issue 1 - p 95–100
doi: 10.1097/PGP.0000000000000298

Cervical carcinoma is the second most common female malignancy worldwide. It usually spreads by direct local extension or the lymphatic vessels. Hematogenous dissemination with distant skeletal muscle metastases is a rare phenomenon. We report here 2 patients whose recurrent squamous cell carcinomas of the cervix presented with symptomatic skeletal muscle metastases affecting the muscles of the thoracic wall and forearm, respectively. We also discuss the differential diagnosis and comprehensively review the previously published literature on this rare presentation of cervical carcinoma.

Departments of Pathology (F.S., A.C., N.I., S.V.)

Oncology (A.T.S., N.K.), University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina

The authors declare no conflict of interest.

Address correspondence and reprint requests to Semir Vranic, MD, PhD Department of Pathology, University of Sarajevo Clinical Center, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina. E-mail:

©2017International Society of Gynecological Pathologists