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Cervical Squamous Cell Carcinoma Metastatic to Placenta

Can, Nhu Thuy T. M.D.; Robertson, Patricia M.D.; Zaloudek, Charles J. M.D.; Gill, Ryan M. M.D., Ph.D.

International Journal of Gynecological Pathology: September 2013 - Volume 32 - Issue 5 - p 516–519
doi: 10.1097/PGP.0b013e3182763178
PATHOLOGY OF THE LOWER GENITAL TRACT: CASE REPORT
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A pregnant 29-year-old gravida 4, para 3 woman with Stage IIB cervical cancer was admitted at 33 weeks and 4 days of gestation and delivered a healthy neonate. Her placenta was small but otherwise grossly unremarkable. Microscopic examination revealed metastatic squamous cell carcinoma. An immunohistochemical stain for p16 was positive in the carcinoma cells, supporting metastasis from the cervical tumor. Cervical squamous cell carcinoma metastatic to placenta is very rare. We report a case and discuss metastatic cancer during pregnancy with recommendations for infant follow-up.

Department of Pathology (N.T.T.C.), University of Chicago, Chicago, Illinois

Departments of Obstetrics and Gynecology (P.R.)

Pathology (C.J.Z., R.M.G.), University of California, San Francisco, California

The authors declare no conflict of interest.

Address correspondence and reprint requests to Ryan M. Gill, MD, PhD, Department of Pathology, University of California, 505 Parnassus Avenue, Room M-545, P.O. Box 0102, San Francisco, CA 94143-0102. E-mail: ryan.gill@ucsf.edu.

©2013International Society of Gynecological Pathologists