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Primary Peritoneal Cancer in Lynch Syndrome: A Clinical–Pathologic Report of a Case and Analysis of the Literature

Ghezzi, Fabio M.D.; Uccella, Stefano M.D.; Cromi, Antonella M.D., Ph.D.; Bogani, Giorgio M.D.; Donadello, Nicoletta M.D.; Riva, Cristina M.D.

International Journal of Gynecological Pathology: March 2013 - Volume 32 - Issue 2 - p 163–166
doi: 10.1097/PGP.0b013e31825ac5c9

Lynch syndrome is a genetic disease, caused by a germ-line mutation in a mismatch repair gene, related to an increased risk of developing colorectal and extracolonic cancer. Despite that, the incidence of primary peritoneal cancer after adnexectomy remains unknown. We here report a case of primary peritoneal cancer in a woman affected by Lynch syndrome who underwent hysterectomy+salpingo-oophorectomy for endometrial cancer 13 yr before. Morphology and immunophenotype allowed to differentiate peritoneal malignancy from the previously diagnosed endometrial carcinoma. Physicians should be aware of the potential risk of primary peritoneal cancer in women affected by Lynch syndrome, despite previous prophylactic surgery.

Department of Obstetrics and Gynecology (F.G., S.U., A.C., G.B., N.D.), University of Insubria, Del Ponte Hospital

Department of Human Morphology (C.R.), University of Insubria, Varese, Italy

The study was conducted in Varese, Italy.

The authors declare no conflict of interest.

Address correspondence and reprint requests to Giorgio Bogani, MD, Department Obstetrics and Gynecology, University of Insubria, Piazza Biroldi 1, 21100 Varese, Italy. E-mail:

©2013International Society of Gynecological Pathologists