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Origin of Uterine Teratoma Differs From That of Ovarian Teratoma: A Case of Uterine Mature Cystic Teratoma

Wang, Wen-Chung M.D., M.S.; Lee, Mour-Shyuarn M.D.; Ko, Jiunn-Liang Ph.D.; Lai, Yen-Chein Ph.D.

International Journal of Gynecological Pathology: November 2011 - Volume 30 - Issue 6 - p 544–548
doi: 10.1097/PGP.0b013e31821c3205
PATHOLOGY OF THE UPPER GENITAL TRACT: CASE REPORTS
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Mature cystic teratomas are usually found in the ovaries and rarely in the uterus. Most teratomas of the uterus are of cervical origin. There are only a handful of reports to date of uterine teratomas arising from uterine corpus. The teratomas of the ovaries and the cervix are thought to be of parthenogenetic origin from oocyte after the completion of the first division. However, the origin of a uterine teratoma has not been established by molecular methods. In this study, we report a 46-year-old woman with a teratoma within uterine corpus. Computed tomography scanning and histological studies after tumor resection confirmed the diagnosis of teratoma. The DNA profiles of normal uterine tissue and teratoma tissue were compared using short tandem repeats analysis and showed that the teratoma did not originate from the parthenogenetic process. Our results suggest that the origin of this uterine teratoma is most likely pluripotential stem cell of uterus or primordial germ cell before meiosis I.

Department of Obstetrics and Gynecology (W-C.W., M-S.L.), Jen-Ai Hospital

Chien-Tien Obstetrics and Gynecology Clinic (M-S.L.)

Institute of Medical and Molecular Toxicology (J-L.K.)

School of Medical Laboratory and Biotechnology (Y-C.L.), Chung Shan Medical University, Taichung, Taiwan

The authors declare no conflict of interest.

Address correspondence and reprint requests to Yen-Chein Lai, PhD, No.110, Sec. 1, Chien Kuo N. Road, Taichung (402), Taiwan, R.O.C. e-mail: yenchein@csmu.edu.tw

©2011International Society of Gynecological Pathologists