Malignant transformation of a uterine leiomyoma is an exceedingly rare phenomenon. Previous reported examples of malignant neoplasms to arise so include leiomyosarcoma, angiosarcoma, and malignant mesenchymoma. We report an intramural carcinosarcoma arising in a uterine leiomyoma in a 38-year-old woman. This case is unique in being the first recorded carcinosarcoma arising within a uterine leiomyoma and the first example of an epithelial neoplasm to do so. We discuss the differential diagnosis and possible pathogenesis of the tumor that has likely arisen secondary to epitheliogenesis in a mesenchymal neoplasm.
Department of Cellular Pathology (D.W.C.), South London Healthcare NHS Trust, Queen Elizabeth Hospital, Woolwich
Department of Cellular Pathology (P.A.M.), Guy's & St. Thomas' NHS Foundation Trust
Department of Obstetrics and Gynaecology (J.V.C.), South London Healthcare NHS Trust, Queen Elizabeth Hospital, Woolwich, London
Department of Pathology (W.G.M.), Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK
The authors declare no conflict of interest.
Address correspondence and reprint requests to Damian W. Collins, FRCPath, Department of Cellular Pathology, South London Healthcare NHS Trust, Queen Elizabeth Hospital, Woolwich, London SE18 4QH, United Kingdom. e-mail: firstname.lastname@example.org