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Dedifferentiated Chondrosarcoma Arising in a Mature Cystic Teratoma of the Ovary: A Case Report and Review of the Literature

Yasunaga, Masafumi M.D., Ph.D.; Saito, Toshiaki M.D., Ph.D.; Eto, Takako M.D.; Okadome, Masao M.D., Ph.D.; Ariyoshi, Kazuya M.D., Ph.D.; Nishiyama, Ken-ichi M.D., Ph.D.; Oda, Yoshinao M.D., Ph.D.

International Journal of Gynecological Pathology: July 2011 - Volume 30 - Issue 4 - p 391–394
doi: 10.1097/PGP.0b013e318211f56e

Malignant transformation of a mature cystic teratoma of the ovary is rare, occurring in approximately 2% of all cases. The most common malignancy arising in mature cystic teratoma is squamous cell carcinoma. Much less frequently, the malignant transformation is represented by sarcomas. Dedifferentiated chondrosarcoma usually develops in bone. There has been no case of a dedifferentiated chondrosarcoma arising in mature cystic teratoma of the ovary since the establishment of this diagnostic entity. This is a report of a definitive dedifferentiated chondrosarcoma arising in a mature cystic teratoma of the ovary, presenting clinicopathologic features.

Gynecology Service (M.Y., T.S., T.E., M.O., K.A.)

Department of Pathology (K.N.), National Kyushu Cancer Center

Department of Anatomic Pathology (Y.O.), Graduate School of Medical Science, Kyushu University Hospital, Fukuoka, Japan.

Address correspondence and reprint requests to Toshiaki Saito, MD, PhD, Gynecology Service, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka 811-1395, Japan. e-mail:

©2011International Society of Gynecological Pathologists