Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Clinicopathologic Correlations Between Human Papillomavirus 16 Infection and Beclin 1 Expression in Human Cervical Cancer

Wang, Zan-Hong Ph.D.; Xu, Li Ph.D.; Wang, Yong Ph.D.; Cao, Ming-Qin Ph.D.; Li, Li Ph.D.; Bai, Tao Ph.D.

International Journal of Gynecological Pathology: July 2011 - Volume 30 - Issue 4 - p 400–406
doi: 10.1097/PGP.0b013e31820f874a

Our earlier study showed that the autophagy gene Beclin 1 could affect cell proliferation in a cervical cancer HeLa cell line. In this study, we examined Beclin 1 protein expression in 81 specimens of cervical squamous carcinoma by immunohistochemistry. Meanwhile, we detected E6 and E7 genes of human papillomavirus 16 in these tissues by polymerase chain reaction. Beclin 1 expression significantly decreased in samples of malignant cervical cancer tissues than in those of normal or cervical intraepithelial neoplasia tissues. The expression of Beclin 1 was associated with pelvic lymph node metastasis and histological grade, but did not correlate with International Federation of Gynecology and Obstetrics stage, age, depth of cervical infiltration, tumor size, and gross type of cervical lesion. The expression of Beclin 1 was not obviously correlated with E6 and E7 genes statistically. Therefore, decreased expression of Beclin 1 may be related to tumorigenesis and the development of cervical cancer, but is not significantly relevant with human papillomavirus 16 infection.

Supplemental Digital Content is available in the text.

Departments of Gynecology (Z-H.W.)

Pathology (T.B.), The First Hospital, Shanxi Medical University, Taiyuan

Department of Respiratory Medicine (L.X.)

Department of Neurology (Y.W.), The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing

School of Public Health (M-Q.C.), Xinjiang Medical University, Urumqi, Xinjiang, China

The research is supported by the National Natural Science Foundation of China (Grant No. 30740016), Shanxi Province Science Foundation for Youths (Grant No. 2008021046-2).

Zan-Hong Wan and Li Xu have contributed equally to the paper.

The authors declare that there are no conflicts of interest in this work.

Supplemental Digital Content is available for this study. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this study on the journal's Website,

Address correspondence reprint request to Zan-Hong Wang, Department of Gynecology, The First Hospital, Shanxi Medical University, Taiyuan 030001, P.R. China. e-mail:

©2011International Society of Gynecological Pathologists