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Malignant Melanoma Arising in an Ovarian Carcinosarcoma: Case Report and Review of the Literature

Roma, Andres A. M.D.; Malpica, Anais M.D.; Deavers, Michael T. M.D.

International Journal of Gynecological Pathology: March 2011 - Volume 30 - Issue 2 - p 158–162
doi: 10.1097/PGP.0b013e3181f9eba5

A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.

Department of Anatomic Pathology (A.A.R.), Cleveland Clinic, Cleveland, Ohio

Departments of Pathology and Gynecologic Oncology (A.M., M.T.D.), The University of Texas M.D. Anderson Cancer Center, Houston, Texas

Address correspondence and reprint requests to Andres A. Roma, MD, Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave, L25, Cleveland, OH 44195. e-mail:

©2011International Society of Gynecological Pathologists