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Evolution of a Trophoblastic Tumor From an Endometrioid Carcinoma—A Morphological and Molecular Analysis

T. Olson, Mathew M.D.; D. Gocke, Christopher M.D.; L. Giuntoli, Robert , M.D.; Shih, Ie-Ming M.D., Ph.D.

International Journal of Gynecological Pathology: March 2011 - Volume 30 - Issue 2 - p 117–120
doi: 10.1097/PGP.0b013e3181f5ce68

We report the clinicopathological and molecular characteristics of a rare uterine endometrioid carcinoma with a nongestational trophoblastic neoplastic component that was composed of both choriocarcinoma and epithelioid trophoblastic tumor. Molecular genetic analysis showed a clonal evolution from endometrioid carcinoma to trophoblastic tumor. The findings from this case have both diagnostic and biological implications that may inspire future studies on the pathogenic mechanisms by which cancer stem cells assume aberrant differentiation programs and the molecular switch(es) that initiates trophoblastic differentiation in adult tumor tissues.

Department of Pathology (M.T.O., C.D.G., I.-M.S.) and Division of Gynecologic Oncology (R.L.G.), Johns Hopkins Medical Institutions, Baltimore, Maryland

Address correspondence and reprint requests to Ie-Ming Shih, MD, PhD, Johns Hopkins Medical Institutions, 1550 Orleans Street, CRB-2, Room 305, Baltimore, Maryland 21231. e-mail:

©2011International Society of Gynecological Pathologists