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COX-2 Expression in Nonepithelial Ovarian Malignancies

Menczer, Joseph M.D.; Schreiber, Letizia M.D.; Sukmanov, Oleg M.D.; Czernobilsky, Bernard M.D.; Berger, Esther Ph.D.; Golan, Abraham M.D., F.R.C.O.G.; Levi, Tally M.D.

International Journal of Gynecological Pathology: January 2011 - Volume 30 - Issue 1 - p 41–45
doi: 10.1097/PGP.0b013e3181f29c6e

The aim of the study was to assess the expression of cyclooxygenases (COX)-2 in nonepithelial ovarian malignancies.

COX-2 immunohistochemical staining was performed on newly prepared deparaffinized slides from formalin-fixed, paraffin-embedded archival tissue blocks of unselected nonepithelial ovarian malignancies diagnosed between January 1993 and October 2009 after reconfirmation of the diagnosis. Staining was assessed according to intensity of staining and the proportion of stained cells. Staining of more than 10% of the cells was considered positive.

During the study period, 26 histologically proven nonepithelial ovarian malignancies were diagnosed. Of them, 16 were granulosa cell tumors and 10 were germ cell tumors (4 dysgerminomas and 6 immature teratomas). Five (31.2%) granulosa cell tumors had positive immunohistochemical COX-2 staining. Positive staining was observed only in 1 immature teratoma and in none of the dysgerminomas.

Our data seem to indicate that COX-2 expression by immunohistochemical methods is not frequent in nonepithelial ovarian malignancies.

Gynecologic Oncology Unit (J.M., A.G., T.L.), Department of Obstetrics and Gynecology

Department of Pathology (L.S., O.S., E.B.), E. Wolfson Medical Center, Holon

Tel Aviv University (L.S., O.S., E.B.), Sackler Faculty of Medicine, Tel Aviv

Patho-Lab Diagnostics (B.C.), Nes-Ziona, Israel

Joseph Menczer and Letizia Schreiber have contributed equally.

Address correspondence and reprint requests to Joseph Menczer, MD, Gynecologic Oncology Unit, E. Wolfson Medical Center, Holon, Israel. e-mail:

©2011International Society of Gynecological Pathologists