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DNA Mismatch Repair Deficiency in Endometrial Carcinoma

Karamurzin, Yevgeniy M.D.; Rutgers, Joanne K. L. M.D.

International Journal of Gynecological Pathology: May 2009 - Volume 28 - Issue 3 - p 239-255
doi: 10.1097/PGP.0b013e31818d8fe6
PATHOLOGY OF THE CORPUS: REVIEW ARTICLE
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Microsatellite instability (MSI) is the hallmark of a molecular pathway to carcinogenesis due to sporadic or inherited abnormalities of DNA mismatch repair genes. Inherited mutations are seen in hereditary nonpolyposis colorectal cancer syndrome. Endometrial carcinoma shows as high an incidence of MSI as does colorectal carcinoma. This review provides a framework for the gynecologic pathologist to understand the complexities of MSI in endometrial carcinoma, by discussing the basic mechanisms of mismatch repair and carcinogenesis, testing, the morphologic features of MSI endometrial cancer and the contradictory data regarding prognosis.

Department of Pathology and Laboratory Medicine (Y.K.), University of California Irvine, Orange, California

Department of Pathology (J.K.L.R.), Todd Cancer Institute, Long Beach Memorial Medical Center, Long Beach, California

Address correspondence and reprint requests to Yevgeniy Karamurzin, MD, University of California Irvine, 101 S The City Drive, Building 10, Orange, California. E-mail: ykaramur@uci.edu

©2009International Society of Gynecological Pathologists