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Subclassification of Ovarian Surface Epithelial Tumors Based on Correlation of Histologic and Molecular Pathologic Data

Gilks, C. Blake M.D.

International Journal of Gynecological Pathology: July 2004 - Volume 23 - Issue 3 - p 200-205
doi: 10.1097/01.pgp.0000130446.84670.93
Review Article

Summary: Surface epithelial tumors are a large and heterogeneous group of neoplasms that are subclassified based on cell type and malignant potential. The objective of this review is to examine the correlations between recent molecular pathology data and the traditional histopathologic classification of surface epithelial tumors. By doing so, 6 distinct subsets of ovarian epithelial neoplasia can be identified with potential treatment implications 1. high-grade serous, high-grade endometrioid, and undifferentiated carcinomas; 2. low-grade serous carcinomas and serous borderline tumors; 3. mucinous carcinomas and mucinous borderline tumors of intestinal type; 4. low-grade endometrioid carcinomas and endometrioid borderline tumors; 5. clear cell carcinomas; and 6. transitional cell carcinomas.

From the Department of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver BC, Canada.

Presented at the Scientific Program of the International Society of Gynecological Pathologists, held in conjunction with the Annual Meeting of the U.S.–Canadian Division of the International Academy of Pathology, Vancouver, B.C., Canada, March 7, 2004.

Address correspondence and reprint requests to Dr. C. Blake Gilks, Dept of Pathology and Laboratory Medicine, Rm 1438, 1st Floor JPPN, Vancouver General Hospital, 855 West 12th Ave., Vancouver BC V5Z 1M9 Canada. E-mail:

©2004International Society of Gynecological Pathologists