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The Histologic Type and Stage Distribution of Ovarian Carcinomas of Surface Epithelial Origin

Seidman, Jeffrey D. M.D.; Horkayne-Szakaly, Iren M.D.; Haiba, Moutaz M.D.; Boice, Charles R. M.D.; Kurman, Robert J. M.D.; Ronnett, Brigitte M. M.D.

International Journal of Gynecological Pathology: January 2004 - Volume 23 - Issue 1 - p 41-44
doi: 10.1097/01.pgp.0000101080.35393.16
Original Contributions
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Advances over the past decade suggest a need to reassess the distribution of ovarian surface epithelial tumors. A series of 220 consecutive invasive ovarian carcinomas, including carcinosarcomas and peritoneal carcinomas, was reviewed. Notable findings include: 7% of tumors were carcinosarcomas; 22% of cases of peritoneal serous carcinomatosis were of peritoneal origin; <3% of cases were mucinous carcinomas; and only one malignant Brenner tumor (0.5%) and no pure transitional cell carcinomas were identified. If peritoneal carcinomas, carcinosarcomas, and mixed carcinomas with a serous component are combined with serous carcinomas, this group accounts for 78% of all cases and 87% of advanced stage cases, suggesting a greater uniformity to epithelial ovarian cancer than previously appreciated.

From the Departments of Pathology (J.D.S., I.H., M.H.) and Obstetrics and Gynecology (C.B.), Washington Hospital Center, Washington, DC; and the Departments of Pathology and Obstetrics and Gynecology (R.J.K., B.M.R.), Johns Hopkins Hospital, Baltimore, Maryland.

Address correspondence to Jeffrey Seidman, M.D., Department of Pathology, Washington Hospital Center, 110 Irving Street, NW, Washington, DC 20010. E-mail: Jeffrey.D.Seidman@medstar.net. Reprints not available.

©2004International Society of Gynecological Pathologists