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Skene's Gland Adenocarcinoma Resembling Prostatic Adenocarcinoma

Pongtippan, Atcharaporn M.D.; Malpica, Anais M.D.; Levenback, Charles M.D.; Deavers, Michael T. M.D.; Silva, Elvio G. M.D.

International Journal of Gynecological Pathology: January 2004 - Volume 23 - Issue 1 - p 71-74
doi: 10.1097/01.pgp.0000101144.79462.39
Case Reports

An 88-year-old woman presented with gross hematuria and a 3-cm periurethral mass. Biopsy revealed an adenocarcinoma resembling prostatic adenocarcinoma; the tumor cells were positive for keratin and prostate-specific antigen. The serum level of prostate-specific antigen was elevated; the carcinoembryonic antigen and CA-125 serum levels were normal. One year after external beam radiotherapy, the patient is without evidence of disease. This is the sixth case of a urethral prostatic-type adenocarcinoma, tumors that are most likely of Skene's gland origin.

From the Departments of Pathology (A.P., A.M., M.T.D., E.G.S.) and Gynecologic Oncology (C.L.), University of Texas MD Anderson Cancer Center, Houston, Texas.

Address correspondence and reprint requests to Elvio G. Silva, M.D., MD Anderson Cancer Center Department of Pathology, Box 85, 1515 Holcombe Boulevard, Houston, TX 77030. E-mail:

©2004International Society of Gynecological Pathologists