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Urachal Adenocarcinoma Metastatic to the Ovaries: Case Report and Literature Review

Ohira, Satoshi M.D.; Shiohara, Shigeki M.D.; Itoh, Kazuko M.D.; Ashida, Takashi M.D.; Fukushima, Mana M.D.; Konishi, Ikuo M.D.

International Journal of Gynecological Pathology: April 2003 - Volume 22 - Issue 2 - p 189-193

We report a urachal adenocarcinoma metastatic to both ovaries in a 50-year-old Japanese woman. Pelvic examination and imaging studies revealed a large cystic tumor occupying the pelvis and another cystic tumor between the umbilicus and the urinary bladder. A laparotomy was performed. Histopathological examination revealed a urachal tumor that was a well-differentiated invasive mucinous adenocarcinoma; the overlying urothelium was intact. The right and left ovarian tumors were well-differentiated mucinous adenocarcinomas. The urachal and ovarian tumors were immunoreactive for cytokeratin 20 and carcinoembryonic antigen, but negative for cytokeratin 7. The patient is alive with lymph node and bone metastases 6 months postoperatively. This is the eighth reported case of an adenocarcinoma of the bladder with ovarian metastasis.

From the Departments of Obstetrics and Gynecology (S.O., S.S., K.I., T.A., I.K.), and Laboratory Medicine (M.F.), Shinshu University School of Medicine, Matsumoto, Japan.

Address correspondence and reprint requests to Satoshi Ohira, M.D., Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.

©2003International Society of Gynecological Pathologists