ORIGINAL ARTICLE: PDF OnlyAdenoid Basal Carcinoma of the Uterine Cervix Detection of Integrated Human Papillomavirus in a Rare Tumor of Putative “Reserve Cell” OriginGrayson, Wayne M.B.ch.B., F.c.Path.(s.A.); Taylor, Louise F.; Tech, Nat Dip Med; Tech, Nat Higher Dip Med; Cooper, Kum M.B.Ch.B., F.F.Path., F.R.C.Path. (U.K.) Author Information Department of Anatomical Pathology. School of Pathology. University of the Witwatersrand. and the South African Institute for Medical Research. Johannesburg. South Africa. International Journal of Gynecological Pathology: October 1997 - Volume 16 - Issue 4 - p 307-312 Buy Abstract Summary This study investigated the role of human papillomavirus (HPV) in adenoid basal carcinoma, a rare neoplasm of the uterine cervix. Nine archival paraffin-embedded tumors were analyzed with non-isotopic in situ hybridization (NISH) for HPV types 6. 11, 16, 18, 31, and 33 using digoxigenin-labelled probes. The polymerase chain reaction (PCR) was performed on each of the cases using E6 consensus primers to HPV. A total of 67% of adenoid basal carcinomas harbored the HPV genome with NISH, of which 3 were PCR-positive. Integrated HPV 16 DNA was demonstrated in 4 of the 6 NISH positive cases. Two cases showed integrated HPV 33. HPV DNA was not detected in the three remaining cases. These results show that the integrated high-risk HPV, in particular type 16, is associated with this uncommon cervical tumor. ©1997International Society of Gynecological Pathologists
