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Morimura Yutaka M.D.; Hoshi, Kazuhiko M.D.; Hang, Xiang Li M.D.; Takano, Yoshimasa M.D.; Ohishi, Man M.D.; Honda, Tsuyoshi M.D.; Yamada, Hidekazu M.D.; Sato, Akira M.D.
International Journal of Gynecological Pathology: October 1996
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Summary

The purpose of this study was to determine whether proliferative activity is a prognostic factor in ovarian clear cell adenocarcinoma. The paraffin-embedded sections from eight cases of ovarian clear cell adenocarcinoma were immunostained with monoclonal antibody MIB1 using microwave oven heating for antigen retrieval. The difference in survival (Kaplan-Meier) between patients with high and low MIB1 expression was estimated with the generalized Wilcoxon test. MIB1 positivity ranged from 1.80 to 27.12% with a mean of 11.43%. A cutoff point of 10% dichotomized patients into two groups. The survival of high (≥=10%) expressing tumors was worse than that of low (<10%) expressing tumors (p < 0.05). MIB1 immunostaining may have useful prognostic value in ovarian clear cell adenocarcinoma.

©1996International Society of Gynecological Pathologists