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Ravn Vibeke; Teglbjaerg, Christence Stubbe; Mandel, Ulla; Dabelsteen, Erik
International Journal of Gynecological Pathology: January 1993
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Cycling endometrial tissue was examined immunohistochemically for blood group antigens using a panel of monoclonal antibodies with specificity to type 1 chain carbohydrates. Staining was evaluated against the genetic background (ABO, Lewis, and saliva-secretor status) and the subphase of the menstrual cycle. Expression of type 1 chain antigens in most cases correlated with the genetic background; however, Lea and Leb antigens were in a few cases demonstrated in endometria with the erythrocyte Lea-b- phenotype and Leb antigen in erythrocyte Lea+b- endometria also. In addition, Leb antigen was preferentially expressed in endometria from blood group O individuals. Type I chain antigens were, in general, maximally demonstrated in the surface epithelium. Chain I A. H, ALeb, Lea, and disialosyl-Lea (dsLea) determinants were demonstrated only sporadically in functionalis and basalis glands of cycling endometria. Staining for most type I chain antigens showed variations that were related to the histomorphology (layer and menstrual phase), and monosialosyl-Lea (msLea) seemed to be a marker of secretory differentiation in the endometrium. Our results support the view that synthesis and expression of type 1 chain antigens in human endometrium is influenced by the genetic background and is modulated by the hormonal environment.

©1993International Society of Gynecological Pathologists