Recent advances in the treatment of renal stones using flexible ureteroscopys

Upper urinary tract stones are a common urological disease that can be treated by flexible ureteroscopy (FURS) through the natural urinary tract, in addition to extracorporeal shock wave lithotripsy and percutaneous nephrolithotomy. The advantages of FURS are less trauma, faster recovery, and fewer complications, while its disadvantages include poor results of lithotripsy and stone extraction when dealing with larger stones, and prolonged operation time. Over the last two decades, the emergence of new technologies such as FURS combined with negative pressure suction, robot-assisted FURS, and artificially intelligent FURS, coupled with improvements in laser technology (the use of thulium fiber lasers and the invention of single-use flexible ureteroscopes (su-fURS) suitable for primary level application, have significantly increased the global adoption of FURS. This surge in usage holds a promising future in clinical application, benefiting a growing number of patients with renal calculi. Accompanied by changes in technical concepts and therapeutic modalities, the scope of indications for FURS is broadening, positioning it as a potential primary choice for urolithiasis treatment in the future. This review outlines the progress in employing FURS for the treatment of renal calculi in order to generate insights for further research.


Introduction
Kidney stones are among the most common clinical disorders of the urinary tract, affecting ~10% of adults worldwide [1] .The main symptoms include pain, hematuria, back pain, and discomfort.If not treated in time, it can lead to disease progression, seriously affecting patient health, and quality of life [1] .With the development of endoscopic equipment and minimally invasive technology, flexible ureteroscopy (FURS) has the advantages of less trauma, quicker recovery, and fewer complications in the treatment of kidney stones compared with traditional extracorporeal shock wave lithotripsy and percutaneous nephrolithotripsy [2] .In recent years, emerging technologies such as FURS combined with negative pressure suction sheath, robot-assisted FURS, and artificially intelligent FURS have received increasing attention from scholars and patients and will play an important role in the future treatment of kidney stones.

History of FURS and its development (Table 1)
The chance finding by Young [3] in 1912 that a dilated ureter allowed visualization of calyces in the renal pelvis via a small cystoscope in a 2-month-old male infant stimulated the development of FURS.Marshall [4] first reported the use of FURS in

HIGHLIGHTS
• Flexible ureteroscopy (FURS) is a safe and effective procedure for treating renal stones.• Thulium fiber lasers rises to become one of the best lithotripsy tools.• The development of single-use flexible ureteroscopes addresses the main limitations of conventional reusable ureteroscopes, enabling the performance of ureteroscopic laser lithotripsy in primary hospitals.• The emergence of new technologies such as FURS combined with negative pressure suction, robot-assisted FURS, and artificially intelligent FURS has further updated FURS.• The scope of ureteroscopic laser lithotripsy applications is expanding.
urology in 1964.The FURS, designed by Curtis et al. [5] , allows visualization of the entire urological lumen and identification of the stone's location.In 1977, Goodman [6] advanced the development and transformation of FURS by inventing ureteroscopy, and incorporating perfusion and working channels based on this innovation.In 1983, the Welch Allyn Company [7] in the United States developed a miniature image sensor, marking a significant breakthrough in the history of endoscopy.This sensor superseded optical-fiber-guided imaging and introduced an era of electronic endoscopy.In 1987, Bagley [8] introduced what is now known as a flexible ureteroscope with a working channel.In 2006, Gyrus ACMI [9] released its first digital ureteroscope.In October 2015, Boston Scientific launched the LithoVue, a mirror body 9.5F, dual-turn, antitorsion device with digital clear imaging.This marked a significant milestone as the first single-use ureteroscope designed for access to the upper urinary tract [10] .In summary, from the widespread application of traditional fiber optic FURS to the emergence of digital FURS, to the emergence of su-fURS , and now to the further improvement of FURS combined with negative pressure suction sheath, robot-assisted FURS, and artificial intelligence FURS [3,11] , both have further expanded the indications for ureteroscopic surgery, benefiting more patients with kidney stones.

Holmium laser lithotripsy
The European Association of Urology (EAU) [12,13] Guidelines on Urolithiasis propose flexible ureteral lithotripsy (FURL) as the first-line treatment option for stones 1-2 cm in the upper urinary tract and as an alternative option for those 2-4 cm in the upper urinary tract stones [14] .Indications (Table 2) for FURL include: a) X-ray negative renal stones (< 2 cm) that are difficult to locate with ESWL; b) lower calyceal stones that remain after ESWL; c) embedded lower calyceal stones (< 2 cm) that are inadequately treated by ESWL; d) cases involving extreme obesity, severe spinal deformity, ectopic kidneys combined with renal stones, and difficulty in establishing a channel for PNL; e) stones that are hard and not conducive to ESWL; and f) renal diverticulum calculi.The effectiveness of holmium laser lithotripsy (HLL) during ureteroscopy for upper urinary tract stones is well-established.HLL was notably more effective for small stones than for larger stones [15] .For kidney stones with a diameter ≥ 2 cm, HLL efficiency is low and staged surgery is often necessary to achieve complete removal [16,17] .PCNL is frequently the preferred approach for kidney stones with a diameter ≥ 2 cm [18,19] .Although the success rate for kidney stone removal is high, complications such as infection, substantial bleeding, hemothorax, pneumothorax, kidney damage, and intestinal harm may also occur [20][21][22] .The success of PCNL depends on several factors, including age, distance of percutaneous renal access, anatomical irregularities, extent of hydronephrosis, and various stone-associated factors such as stone burden, location, morphology, density, and number [22] .Therefore, according to the EAU guidelines, FURL is recommended in cases where there are contraindications to PCNL (such as an uncorrected risk of bleeding) or for patients who do not wish to undergo PCNL.
The decision to intervene surgically for small renal stones (< 2 cm) is related to stone characteristics, co-morbidities, patient renal anatomy, and patient selection [12] .Surgical intervention should be aggressively pursued in the following cases: 1. the presence of residual stones despite pharmacological treatment, 2. a high risk of hydronephrosis due to stone drop in isolated kidneys or renal calyces (more common in the mid-ureteral and ureteral junctions), and; 3. recurrent symptoms such as renal colic [23] .It has been suggested that urolithiasis is the most common cause of renal forniceal rupture (73%), whereas most cases are due to small stones (1-5 mm) in the distal ureter (61%) [24] .Therefore, lithotripsy surgery for renal stones <2 cm is required when above symptoms are present.
The 2022 edition of the 'Guidelines for the Diagnosis and Treatment of Chinese Urology and Andrology Diseases' [25] advises that PCNL is preferrable for kidney stones ≥ 2 cm, whereas ureteroscopy is a viable alternative.Nevertheless, as ureteroscopy technology, supplementary lithotripsy, and stone removal instruments continue to evolve and refine, the use of FURL has gradually become more widespread.
Fiber ureteroscopy combined with a holmium laser is a widely used clinical treatment for patients with kidney stones.In a randomized controlled study of 111 patients, Hao et al. [26] determined that FURL accelerates postoperative recovery, reduces the incidence of adverse reactions, alleviates pain, and enhances the quality of life in patients with kidney stones measuring 2-3 cm, without significantly affecting urea nitrogen and serum creatinine levels.Yu et al. treated 113 pediatric patients with kidney stones > 2 cm in size between June 2014 and October 2019 using two different surgical methods: PCNL and FURL.The stone-free rates of PCNL and FURL were 80.9% (34/42)  be concluded that FURL has almost the same stone clearance effect as PCNL in the treatment of pediatric renal calculi larger than 2 cm, and its safety is higher, which may shorten the postoperative hospital stay and reduce iatrogenic trauma [27] .However, one study [28] investigating the management of kidney stones ranging from 2 to 4 cm showed that the PCNL group had a primary stone free rate (SFR) of 91.7%, which was significantly higher than the 74% SFR reported by the retrograde intrarenal surgery (RIRS) group (P = 0.04).Regarding the cost of the procedure, an analysis of outcomes and costs after mini-percutaneous nephrolithotomy (mPCNL) or FURL for the treatment of 1-2 cm renal calculi, based on data from a prospective randomized clinical trial by Dutta et al. [29] showed that the direct cost of mPCNL was higher than that of FURL (P < 0.05).However, a retrospective analysis by Bagcioglu et al. [30] suggested that the use of mPCNL is less expensive than FURL due to the additional processing and ancillary equipment required for FURL.Another study performed a cost-benefit analysis (CBA) and calculated a benefit-cost ratio (BCR), concluding that reusable ureteroscopes are cost-effective in centers with high case volumes [31] .However, comparative studies evaluating cost-effectiveness are scarce.The main problem with cost-effectiveness studies is that both the costs and benefits vary among different institutions and countries, necessitating careful and cautious interpretation.Continuous saline infusion is essential for achieving a clear surgical field during HLL under ureteroscopy.If the drainage is not smooth, an increase in renal pressure (IRP) can develop [32] .Recent research indicates a strong link between intrarenal pressure (IRP) and intrarenal body temperature (IRT).IRP is contingent on inflow and outflow levels, whereas IRT relies on laser parameters and irrigation flow rates.Not all the laser energy emitted during high-power laser lithotripsy is applied to the stone.The remaining energy is absorbed by the water, which increases the IRT [32] .As previously stated, higher IRT levels are linked to elevated pulse rates [33] .Temperature can reach 60°C after 10 s of laser activation at 40W [34,35] .Hence, consistent monitoring is crucial for preventing surgical and infectious complications [36] .When the IRP exceeds 30 mmHg and persists for over 45 s, the postoperative infection rate increases 3.277 fold compared to an IRP of ≤ 30 mmHg, and development of systemic inflammatory response syndrome becomes more likely.Furthermore, an extended surgical duration increases the vulnerability of the renal pelvic mucosa, which in turn facilitates the entry of infectious materials into the bloodstream, ultimately causing sepsis.
When the stone load increased, numerous small fragments tended to cover the surface of the residual stone during lithotripsy.This results in decreased operator observation and makes it impossible for the laser to contact the residual stone directly.Consequently, lithotripsy efficiency was reduced, and the surgical time was significantly prolonged.Furthermore, continued pressurized perfusion and flushing may result in blood escaping from the mucosa of the renal pelvis and calyces, and a significant quantity of stone powder suspension can cause the flushing fluid to become cloudy, triggering a further decrease in visual clarity [37] .The blizzard phenomenon [38] , formed by stone fragments during surgery, can negatively affect the judgment of the visual field and the lithotripsy effect, ultimately leading to insufficient lithotripsy.Therefore, staged surgery may be a reasonable plan for improving the efficacy of flexible ureteroscope for kidney stones > 2 cm.
The removal of stones after lithotripsy is a crucial factor to consider during ureteroscopic surgery.Surgery may involve the use of a stone basket to retrieve slightly larger stones.However, this repeated grasping process carries the risk of damaging the mucosa and prolonging surgical time.For smaller fragments, complete removal may not be possible, and there is a high risk of subsequent ureteral stone street development.The formation of stone streets is related to the following factors: (1) presence of large leftover stones, (2) damage or blockage of the ureter, (3) inability to extract stones, and (4) persistence of blood clots and discharge.Therefore, researchers have suggested [37] utilizing a high-frequency (40-50 Hz), low-energy (0.2-0.4 J) holmium laser to pulverize stones as much as possible during surgery, resulting in stone fragments <2 mm, achieving self-discharge, decreasing treatment expenses, and enhancing patient contentment.
In summary, the combination of conventional ureteroscopy and HLL has a stone clearance rate equivalent to that of PCNL in the treatment of patients with stones smaller than 2 cm.However, there are also limitations to consider, particularly uncontrollable IRP and inadequate postoperative stone clearance rates for patients with stones larger than or equal to 2 cm.

Endoscopic combined intrarenal surgery for large kidney stones
As previously mentioned, PCNL, which is recommended by the EAU guidelines, remains the first choice for renal stones larger than 2 cm in diameter.FURL can be considered if contraindications to PCN exist.For complex renal stones, PCNL usually requires the creation of two or more channels to improve SFR; however, as the number of channels increases, renal parenchymal injury is progressively aggravated, and the rate of complications such as bleeding is increased [39,40] .In recent years, to improve SFR and reduce complications associated with multichannel PCNL, some studies have proposed that PCNL combined with FURL is safe and effective in the treatment of kidney stones.
Gao et al. [41] conducted a study on subgroups of patients with unilateral complex renal stones treated between March 2013 and December 2016.The study included 40 in the super-mini-PCNL group (SMP group), 55 in the FURL group, and 45 in the combined SMP and FURL group.The postoperative 3-day SFR in the SMP group, FURL group, and the combined group were 77.5, 78.2, and 97.8%, respectively (P = 0.010).Intraoperative blood loss, operative time, and hospital stay were significantly lower in the combined group than in the SMP group but higher than in the FURL group.The conclusion was that SMP combined with FURL is an effective method for the treatment of complex renal calculi.
Similarly, Ding et al. [42] retrospectively analyzed data from 92 patients treated with SMP combined with FURL (Group A) and 113 patients treated with FURL alone (Group B) between January 2018 and December 2022.The results revealed that the 3-day postoperative SFR was significantly higher in Group A (85.87%) compared to group B (72.57%) (P = 0.021).The retreatment rate in group A ( 3.26%) was significantly lower than that of group B (10.62%) (P = 0.044).The SFR at 3 months was higher in group A (94.57%) than in group B (90.27%) (P = 0.254).Apart from the differences in operation time, 12 h and 24 h postoperative VAS scores, and complication rates, which were not statistically significant, the mean hemoglobin drop, 6 h postoperative VAS scores, and postoperative hospital stay were significantly higher in group A than in group B (P < 0.05).Finally, it was concluded that SMP combined with FURL has the advantage of higher early SFR with no increased risk of complications compared to FURL in the treatment of complex kidney stones.
It has also been suggested that the combination of FURL and SMP is a minimally invasive, safe, and effective procedure for the removal of multiple kidney stones in selected cases, particularly pediatric patients with multiple kidney stones.No patients experienced severe postoperative bleeding or transfusion; discharge from the hospital occurred 2-5 days after the procedure, and imaging conducted 3 months later revealed no residual stones [43] .

Thulium laser lithotripsy
The holmium laser is the 'gold standard' for laser lithotripsy, and the energy it generates can vaporize water between the end of the fiber and the stone, thereby crushing the stone with micro-blasts.
TFL have emerged as the sharpest tools for stone crushing in recent years.
In a prospective study [44] by Corrales and Traxer involving 50 cases treated with TFL for ureteral and renal stones, 200 μm and 150 μm TFL were used for ureteral and renal stones, respectively.Both groups demonstrated a low overall complication rate, leading to the conclusion that TFL is a safe and effective method for interstitial lithotripsy in RIRS.In another study by Vaddi et al. [45] , 126 patients treated with a 60W TFL developed hematuria in 12 cases and fever in 9 cases, which were Clavien class 1-2.The overall SFR was 93.6% and the complication rate was 16.6% (21/126).Ultrapulsed TFL was equally efficient and safe.
The authors converted electrical energy into light energy with higher conversion efficiency and better beam quality compared to holmium lasers.The generated laser beam is more uniform, has better focusability, and can be transported through finer optical fibers, providing a larger perfusion space, wider pulse repetition frequency range, and lower pulse energy.The superpulse mode significantly improves the efficiency of stone ablation and reduces the incidence of stone regression.In addition, it has a shallow tissue penetration depth and good hemostatic performance.Therefore, TFL may replace holmium lasers in the future due to these advantages [47][48][49][50] .However, the thulium laser has some shortcomings; with a wavelength of 1950 nm, it has a higher water absorption coefficient, higher ablation efficiency, and higher energy absorption.Nevertheless, this higher rate of energy transfer to the stone and surrounding fluid can result in thermal damage to the uroepithelium [51] .Sierra et al. conducted an in vitro study on thermal damage and laser efficiency of TFL and concluded that thermal damage increased progressively with rising output energy.More thermal damage was observed with less experienced operators in a high-frequency environment [52] .Both the holmium and TFL produced elevated ureteral fluid temperatures in a series of tests performed in clinical power settings.Within 60 s of continuous laser activation, the thulium laser produced significantly higher mean ureteral fluid temperatures than the holmium laser at all power levels tested (P < 0.001).At 30 W, the thulium laser was 11% warmer than the holmium laser, exceeding 43°C [51,53] .

Single-use flexible ureteroscopes
In recent years, su-fURS and semi-rigid ureteroscopes have been developed as alternatives to reusable ureteroscopes.These disposable devices aim to address the issues associated with reusable ureteroscopes, including the substantial expenses related to the procurement, sterilization, handling, upkeep, and repair of instruments [54] .By eliminating the need to disinfect optical cables, the likelihood of maintenance-induced and sterilizationinduced damage is diminished, resulting in a decreased probability of infections related to device use.
Marchini et al. [55] demonstrated that, regarding usage, SFR and complications were comparable between disposable and reusable ureteroscopes.Bragaru et al. [56] supported this by noting that disposable fURS is as effective in treating kidney stones as reusable fURS.Goger et al. [57] revealed that clinical effectiveness and complication rates were comparable when utilizing RIRS for the treatment of renal calyceal stones.Bragaru et al. [58] further demonstrated that the SFR for three types of su-fURS, namely, Uscope 3022, LithoVue, and EU scope, is marginally superior to that of patients who typically undergo reusable fURS treatment.Moreover, Patil [59,60] suggested that various types of sufURS exhibit similar clinical performance.At a particular distance, all the fURS provided equivalent image resolution and power.The irrigation flow of all scopes was uniform in both the deflected and undeflected states when the working channel was empty.
Despite these advantages, sufURS has gained popularity among urologists.However, some scholars argue that [61] while sufURS may address the limitations of reusable ureteroscopes, it high cost and environmental concerns require further investigation and resolution before routine implementation.Taguchi et al. [62] conducted a micro-cost comparison between a reusable flexible ureteroscope (URF-P6) and LithoVue, with a total cost per ureteroscope of $2799.72 and $2852.29 for the URF-P6 and LithoVue, respectively.The cost of repairing flexible ureteroscopes varies depending on the model and type of breakage.According to Kramolowsky et al., the total cost per repair for the URF-P6 (Olympus) ranged from $233 to $7521, with an average cost of $355 per case.For the URF-V series (Olympus), the total maintenance cost was $119 632, with an average cost per box of $511 [63] .In a prospective cohort study, reusable ureteroscopy costs were $1212 and $1743, compared to $1300 to $3180 for single-use ureteroscopy procedures [64] .To date, only one study has specifically evaluated the environmental life cycle of the LithoVue versus the Olympus Flexible Video Ureteroscope (URV-F).Davis et al. [65] concluded that, overall, the LithoVue (4.43 kg) has a comparable carbon footprint to the URV-F (4.47 kg), without considering factors such as natural resources, greenhouse gas emissions from incineration, and landfill waste.
It has been suggested that su-fURS may be used to preserve ru-fURS in complex urological cases with a high risk of endoscopic injury or fracture.The use of su-fURS may be influenced by the volume of the procedure, the limited availability of sterilization equipment, the durability of ru-fURS, and the potential risk of infectious complications [66] .Adoption of a standardized technology known as ureteroscopic HLL is widespread in the field of urology in China.However, most urology departments offer a limited number of reusable ureteroscopes, necessitating prompt disinfection after each use.This requires a meticulous level of disinfection and waiting for an appropriate disinfection time.In cases of equipment damage, ureteroscope repair requires an extended period.Hence, the scenario of 'supply not meeting demand' is certain to arise, leading to a shortage in procurement at high costs.Subsequently, this impact the ability of community hospitals to perform surgeries.Nevertheless, the advent of su-fURS presents an opportunity to redress the situation, potentially enabling the rational allocation of medical resources and yielding enhanced benefits to a larger patient population.

Combined negative pressure suction sheath
To address the issue of elevated pressure in the renal pelvis during ureteroscopic lithotripsy and the inclination of leftover stone fragments to generate stone streets postoperatively, negativepressure suction technology has been integrated with ureteroscopic lithotripsy.
Deng et al. [67] previously developed a UAS for the ureteral pathway equipped with a suction and perfusion platform and a pressure-sensitive tip.Using advanced computer technology, the system records and monitors real-time RPP, allowing for accurate adjustment of the perfusion flow rate and vacuum suction.The authors observed that the actual IRP remained <30 mmHg, resulting in a clear intraoperative field of view.Postoperative SFR was 90.0 and 95.6% at 1 month.The automated RPP control makes this system safe and effective for treating kidney stones.
De Coninck et al. [68] colleagues previously proposed that maintaining a ureteroscopy-to-UAS diameter ratio of less than 0.75 can keep IRP below the renal pelvic venous reflux threshold (40-60 cmH2O) when the pressure surpasses 200 cmH2O during forced perfusion.
One prior study [69] showed that when utilizing negative pressure suction devices alongside FURS and PCNL for treating solitary kidney stones measuring 2-3 cm, the FURS group showed a shorter hospital stay than the PCNL group.Furthermore, the PCNL group required more painkillers than the FURS group.Nevertheless, there was no significant difference in the mean surgical duration or stone clearance between the two groups.Both surgical techniques are equally safe and efficient.However, FURS is superior to RIRS in terms of length of hospital stay, occurrence of complications, and blood loss.
A study conducted by Zewu et al. [70] found that using a combination of ureteroscopy and a negative-pressure suction sheath in the treatment of kidney stones resulted in a higher timely SFR, shorter surgical time, and lower incidence of infectious complications compared to using an ordinary sheath.Similarly, Huang et al. enrolled 371 patients who had received successful fURL treatment in their study.These patients were subsequently categorized into two distinct groups: the traditional fURL group and the vacuum-assisted dedusting lithotripsy (VADL) group.After performing a 1:1 propensity score matching analysis to compare the outcomes of the two groups, a stratified analysis was performed based on stone size and location.The results showed that the use of VADL technology can significantly enhance postoperative SFR in patients with renal stones or stones <3 cm in the proximal ureter treated with ureteroscopy [71] .
A safe and efficient device, the omnidirectional (OD) ureteral access sheath (UAS), was first described by Jie et al. [72] in their recent study.The OD UAS had a deflection angle of ~110-130°w hen not loaded, and 90-130°when loaded with various instruments.The distinctive pliable construction of the device enables it to navigate the renal calyces and locate stones in conjunction with a flexible ureteral endoscope.The OD UAS connects to the suction port, improves the single SFR, and simplifies high-load kidney stone treatment, while reducing the operative duration.
The technique of combining ureteroscopy with negative pressure suction HLL is highly effective for pulverizing even large kidney stones (Fig. 1).This approach not only improves the overall lithotripsy efficiency but also reduces the incidence of stone streets, thus allowing for a wider range of indications for lithotripsy.However, the placement of a negative pressure suction sheath as a ureteral access sheath (UAS) increases the risk of ureteral wall ischemia and injury to the ureteral mucosa or muscularis propria, which theoretically increases the risk of ureteral stricture [73] .There is also a disadvantage related to difficulty in dealing with infrarenal calyx stones due to the restricted bending angle and postoperative pain [74] .

Robot-assisted FURS, artificial intelligence FURS
In 2008, researchers used the Sensei Magellan System (designed specifically for interventional cardiology) FURS robot for 18 clinical trials.However, it was discontinued due to its ability to passively manipulate the ureteroscope [11] .The Roboflex Avicenna, designed specifically for FURS, consists of a manipulator to operate the ureteroscope and a surgeon's console.This console facilitates fine adjustment of the scope, automated insertion and removal, and repositioning establishing a suitable and safe platform for robotic FURS with significantly improved ergonomics.The surgeon can perform stable and precise surgical operations while seated at the open console, as well as laser techniques and fluoroscopy via the touch screen and foot pedals, significantly increasing efficiency and comfort while reducing the surgeon's exposure to radiation [75][76][77][78] .
In a study by Chen et al. in which AI-controlled pressure FURS and MPCNL were used for the treatment of 2-3 cm isolated renal stones, AI-controlled pressure group exhibited advantages such as a shorter hospital stay [(3.53 1.25) d < (6.54 2.36) d] and fewer complications.In addition to pressure control, in lithotripsy, the AI can preset the laser lithotripsy program, set the optimal parameters, and blast with extreme speed for instantaneous lithotripsy [69] .Recent research reports the emergence of a new FURS robot with a force feedback function.Using a neural network-based approach to estimate the interaction force between the flexible ureteral scope and the environment, the operator can accurately perceive obstacles when the interacting axial force or torque exceeds 1.2 N or 15.6 mN•m, respectively, during the robot's teleoperation of the flexible ureteral scope.This force feedback greatly improves the accuracy of the operator's obstacle perception and is expected to improve the safety of robotic-assisted FURS [79] .

Complications and management methods after ureteroscopic surgery
After more than half a century of development and enhancement, ureteroscopic lithotripsy has evolved into a minimally invasive procedure [23] .However, postoperative complications remain a significant problem [80] , and may include: 1. Surgical injuries such as submucosal false channel, mucosal injuries, ureteral perforations, and ureteral avulsions.2. Complications related to perfusion pressure, including infection, urinary sepsis, bleeding, perirenal fluid accumulation, and renal rupture.3. Issues related to ureteral stents, including improper stent placement and symptoms related to ureteral stents.4. Others, such as postoperative bladder ureteral reflux and long-term ureteral stenosis.A careful and expert lithotripsy process can markedly reduce the postoperative complications associated with surgical injuries.Most submucosal false channel can be successfully restored by implanting a stent that remains for 2 weeks (crossing the injury plane), or by a direct visual operation that effectively minimizes the injury.For example, in cases of bleeding, accumulation of fluid around the kidney, and rupture of the kidney, most patients can be treated conservatively (bed rest, blood transfusion, etc.) and recover without requiring surgical intervention.Nevertheless, if required, perirenal drainage and interventional treatment may be considered, with the possibility of nephrectomy [81,82] .The incidence of stent-related symptoms is high and has a significant impact on patient quality of life.A large number of studies have confirmed that M-receptor blockers and α-receptor blockers can effectively alleviate related symptoms [83] , but there is still controversy over whether the combination of the two has a greater effect than one plus one.
It should be noted that the overall complication rate after FURL is 9-25% [13] .Mostly postoperative infections such as urinary tract infections (UTI), urosepsis (severe infections), etc.The incidence of urosepsis ranges from 0.5 to 11.1% and that of septic shock from 0.3 to 4.6% [84] .However, given the seriousness and life-threatening nature of urosepsis, it is important to understand its potential risk factors.
In addition, Sun et al. [87] concluded that postoperative infectious complications were associated with female sex, diabetes mellitus, preoperative and postoperative stent placement, and longer duration of surgery.However, a positive preoperative urine culture was the most important risk factor (OR 2.95, 95% CI: 1.96-4.43,P < 0.01).Therefore, patients with positive urine cultures should receive adequate preoperative antibiotic treatment based on the results of drug susceptibility testing.Patients with negative urine cultures should receive prophylactic antibiotic treatment once on the day of surgery, while a ureteroscopic sheath should be used during surgery to improve intraoperative drainage, control perfusion pressure, and control hand surgery time, which can effectively reduce the risk of postoperative infection.Surgical treatment may be staged in cases with high loads and infectious stones.For patients who have already developed urinary sepsis, it is best to use potent antibiotics within 1 h of onset, actively maintain circulatory stability, maintain water-electrolyte and acid-base balance, support the use of glucocorticoids, and, if necessary, use fresh frozen plasma and other blood products to prevent disseminated intravascular coagulation (DIC).In recent years, clinical trials have confirmed the efficacy of bundle therapy in treating septic shock.Implementing bundle therapy for early infectious septic shock has proven effective in improving medical staff compliance with septic shock treatment, enhancing patient blood circulatory function, and decreasing patient mortality rates.Not only does it have significant clinical practical value, but it can also substantially lower medical expenses and ease the burden of treatment costs on the families of patients [88][89][90] .

Outlook and conclusion
In summary, the scope for the application of ureteroscopy for the treatment of kidney stones is constantly expanding due to the ongoing development of ureteroscopy technology, frequent updates to lithotripsy auxiliary equipment, and the continuous improvement of lithotripsy lasers.In the future, Roquero et al. aims to enhance ureteroscopic surgery using the stone debris removal system (MagSToNE).This system consists of magnetic hydrogel, magnetized stone fragments, and a magnetic wire to remove the fragments.Additionally, In the future, RIRS may be an alternative therapy to PCNL, with acceptable efficacy and complication rates for renal stones [91] .The negative-pressure suction sheaths play an important role in the treatment of kidney stones with a diameter ≥ 2 cm by maintaining an appropriate level of intraoperative renal pelvic pressure, maintaining a clear field of view during surgery, improving stone removal efficiency, accelerating stone removal speed, shortening surgical time, and reducing postoperative complications such as infection and bleeding.TFL are thinner, allowing more room for maneuver, and its ultrapulsed mode of operation significantly improves stone ablation efficiency while reducing the incidence of stone regression.Disposable ureteroscopy can reduce the incidence of instrument-related infections, allowing primary lithotripsy to be performed.Currently, there is very little research on the treatment of kidney stones using disposable ureteroscopy combined with negative-pressure suction and sheath thulium laser.We believe that the combination of the three could bring good news to patients with kidney stones by reducing trauma, alleviating pain, and accelerating recovery.
In the foreseeable future, the application of Roquero et al.'s stone removal system (MagSToNE), which incorporates a magnetic hydrogel for wrapping and magnetizing stone fragments and a magnetic wire for removing the fragments), as well as the advent of ultra-fine flexible endoscopes and lithotripsy robots, will further advance ureteral flexible endoscopy.As urology transitions into the era of minimally invasive and intelligent surgery, multidisciplinary associations such as artificial intelligence and medical-industrial crossover may present the future trend of FURS development.Simultaneously, an increasing number of urologists will become proficient in the use of FURS through the use of 3D printing technology and virtual reality simulators with realistic visual effects, which will increase the enjoyment of training and keep training costs reasonable [92][93][94] .
He et al.International Journal of Surgery (2024)

Figure 1 .
Figure 1.Ureteroscopy combined with negative pressure suction for holmium laser lithotripsy for extracting stone fragments after surgery.

Table 1
Development history of ureteroscopy.-month-oldboy with a dilated ureter, allowing visualization of the renal calyces in the renal pelvis with a small cystoscope 1957 Curtiss, Hirschowitz Created the first soft endoscopes through combining a large number of glass fiber payloads into a bundle and fusing these fibers together at the end so that they could move independently according to their lengths 1964 MarshallReported for the first time the use of flexible ureteroscope in urology to be able to visualize the entire urinary lumen and define the site where the