REVIEWNoradrenaline in mood and anxiety disorders: basic and clinical studiesBrunello, Nicoletta; Blier, Pier; Judd, Lewis L.; Mendlewicz, Julien; Nelson, Craig J.; Souery, Daniel; Zohar, Joseph; Racagni, GiorgioAuthor Information a Center of Neuropharmacology, University of Milan, Italy b Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy c Departments of Psychiatry and Neuroscience, University of Florida Brain Institute, Gainesville, USA d Department of Psychiatry, University of California, San Diego, USA e Free University of Brussels, Brussels, Belgium f Yale University School of Medicine, New Haven, USA g The Chaim Sheba Medical Center, Sackler School of Medicine, Tel-Hashomer, Israel h IRCCS Fatebenefratelli, San Giovanni di Dio, Brescia, Italy Correspondence and requests for reprints to Professor Nicoletta Brunello, Center of Neuropharmacology, Institute of Pharmacological Science, Via Balzaretti 920133, Milan, Italy Tel: +39 02 5031 8331; fax: +39 02 5031 8278; e-mail: [email protected] Received 6 March 2003 Accepted 11 March 2003 International Clinical Psychopharmacology: July 2003 - Volume 18 - Issue 4 - p 191-202 Buy Abstract The neurotransmitter noradrenaline is known to be involved in a range of physiological and psychological processes, and dysfunctions of this neurotransmitter system have been implicated in a range of psychiatric disorders. However, the clinical utility of targeting the noradrenergic system in the treatment of such disorders has been somewhat overshadowed by the availability of agents selective for the serotonin system. A number of antidepressants with increased, but varying, selectivity for the noradrenergic system have become available in recent years, including mirtazapine, bupropion and, most recently, the first truly selective noradrenaline reuptake inhibitor, reboxetine. This review brings together current thinking on the role of noradrenaline in the aetiology and therapy of mood disorders to encourage a rational, evidence-based approach to the treatment of such disorders, and to provide suggestions and guidelines for future research in the area. Copyright © 2003 Wolters Kluwer Health, Inc. All rights reserved.