Original articleInvestigating the psychological effects of home quarantine during the early peaks of the COVID-19 pandemic: a survey from IranNahidi, Mahsaa; Ghalandarzadeh, Mojtabaa; Sinichi, Farideha; Sahebzadeh, Narjesa; Eslami, Saeidb,e; Reihani, Hamidrezac; Emadzadeh, Maryamd; Fayyazi Bordbar, Mohammad Rezaa Author Information aPsychiatry and Behavioral Sciences Research Centers bDepartment of Medical Informatics, Faculty of Medicine cDepartment of Emergency Medicine, Faculty of Medicine dClinical Research Development Unit, Ghaem Hospital ePharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Received 14 June 2022 Accepted 17 September 2022 Correspondence to Mohammad Reza Fayyazi Bordbar, MD, Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, 9195983134 Iran, Tel: +985137112723; e-mail: [email protected] International Clinical Psychopharmacology: November 11, 2022 - Volume - Issue - 10.1097/YIC.0000000000000444 doi: 10.1097/YIC.0000000000000444 Buy PAP Metrics Abstract We assessed psychological symptoms among individuals who were quarantined during early coronavirus disease 2019 (COVID-19) peaks. This cross-sectional study was performed during April–October 2020 in Iran. We surveyed 100 individuals with COVID-19 patients in their families and 100 others with health conditions associated with a higher risk of developing critical forms of COVID-19 infection, who have completed at least 14 days of home quarantine. Validated Persian versions of the 21-item Depression, Anxiety, and Stress and 22-item Impact of Event Scale-Revised were used to measure the symptoms of depression, anxiety, stress and distress. The rates of stress, anxiety, depression and quarantine-related distress were 46.5, 48.5, 57.0 and 80.5%, respectively; however, they were not significantly different between the contact and no-contact groups. Female sex and being unemployed were significantly associated with quarantine-related distress, P = 0.007 and P = 0.018, respectively. Independent risk factors for anxiety were a history of medical comorbidity (P = 0.025) and contact with COVID-19 patients (P = 0.007). Findings show high prevalence rates of psychological symptoms among quarantined individuals, regardless of whether they had contact with COVID-19 patients or not. Female sex and unemployment were risk factors for quarantine-related distress. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.