Original ArticlesPredictors of long-acting injectable antipsychotic treatment discontinuation in outpatients with schizophrenia: relevance of the Drug Attitude Inventory-10Tatini, Lorenzoa; D’Anna, Giulioa; Pietrini, Francescob; Calligaris, Eugeniaa; Ballerini, Andreaa; Ricca, ValdoaAuthor Information aPsychiatry Unit, Department of Health Sciences, University of Florence bDepartment of Mental Health and Addictions, Central Tuscany NHS Trust, Florence, Italy Received 12 January 2021 Accepted 16 March 2021 Correspondence to Lorenzo Tatini, MD, Psychiatry Unit, Department of Health Sciences, University of Florence, Largo Brambilla 3 – 50134 Florence, Italy, Tel: +39 055 7947487; fax: +39 055 7947531; e-mail: [email protected] International Clinical Psychopharmacology: July 2021 - Volume 36 - Issue 4 - p 181-187 doi: 10.1097/YIC.0000000000000359 Buy Metrics Abstract Given the importance of patients’ subjective experience and attitudes in the management of severe mental illness, the present study evaluated their potential role as predictors of future continuation of long-acting injectable antipsychotic maintenance treatment (LAI-AMT) in clinically stable outpatients with schizophrenia switching from an oral therapy. Retrospective data from 59 subjects receiving LAI-AMT for at least 6 months were collected. Patients who continued LAI treatment (n = 32) were compared to those who discontinued it (n = 27), assessing baseline socio-demographic and clinical characteristics, psychopathological features (Positive And Negative Syndrome Scale, Montgomery–Åsberg Depression Rating Scale and Young Mania Rating Scale) and patient-reported experience of treatment through Drug Attitude Inventory 10-item (DAI-10) and Subjective Well-being under Neuroleptics short form. Binary logistic and Cox regression analyses explored the predictive role of the mentioned variables on treatment discontinuation. The Kaplan–Meier estimator compared dropout from LAI treatment in subsamples with different characteristics. Unemployment and lower baseline DAI-10 scores predicted LAI-AMT discontinuation. No major differences were detected in other socio-demographic, clinical or psychometric indexes. When switching from oral to LAI-AMT, the preliminary assessment of attitude towards drug might be clinically relevant, allowing the identification of patients at risk for treatment discontinuation. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.