Case ReportRapid improvement of obsessive-compulsive disorder associated with schizophrenia with cariprazine add-on in a subject under paliperidone long-acting injection a case reportDe Berardis, Domenicoa,,b; Vellante, Federicaa,,b,,c; Fornaro, Michelec,,d; Orsolini, Laurac,,d,,e; Valchera, Alessandroc,,d,,e,,f; Baroni, Gaiab; Kim, Yong-Kug; Martinotti, Giovannib; Di Giannantonio, MassimobAuthor Information aNational Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital ‘G. Mazzini,’ ASL 4 Teramo bDepartment of Neurosciences and Imaging, Chair of Psychiatry, University ‘G. D’Annunzio,’ Chieti cPolyedra Association, Teramo, Italy dFederico II University, Department of Psychiatry, Naples eSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK fVilla S. Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy gCollege of Medicine, Korea University, Republic of Korea Received 6 May 2019 Accepted 2 July 2019 Correspondence to Domenico De Berardis, MD, PhD, National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, ‘G. Mazzini’ Hospital, Piazza Italia 1, 64100 Teramo, Italy, Tel: +39 0861429708; fax: +39 0861429709; e-mail: email@example.com International Clinical Psychopharmacology: March 2020 - Volume 35 - Issue 2 - p 113-118 doi: 10.1097/YIC.0000000000000284 Buy Metrics Abstract Obsessive-compulsive disorder is often associated with schizophrenia and may represent a significant challenge in the treatment as this comorbidity may not respond properly to antipsychotic medication and usually require a pharmacological and psychotherapeutic add-on. In the present case report, we present the case of a 26-year-old male blue-collar subject who developed obsessive-compulsive disorder after a year of complete remission of schizophrenia symptoms under paliperidone long-acting injection that rapidly resolved after low-dosage cariprazine add-on. No adverse effects were reported due to cariprazine- paliperidone long-acting injection combination. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.