Review ArticlesOphthalmic adverse effects of lithiumPark, John S.Y.a,,*; Sharma, Rahul A.a,,*; Sharma, VerinderbAuthor Information aDepartment of Ophthalmology, The Ottawa Eye Institute, University of Ottawa, Ottawa bDepartment of Psychiatry, Western University, London, Ontario, Canada * Dr. John S.Y. Park and Dr. Rahul A. Sharma contributed equally to the writing of this article. Received 11 July 2019 Accepted 14 October 2019 Correspondence to John S.Y. Park, MD, Department of Ophthalmology, The Ottawa Eye Institute, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H 8M2, Canada Tel: 613 798 5555; fax: 613 761 4462; e-mail: firstname.lastname@example.org International Clinical Psychopharmacology: March 2020 - Volume 35 - Issue 2 - p 69-73 doi: 10.1097/YIC.0000000000000295 Buy Metrics Abstract Lithium is the current mainstay treatment for both acute and maintenance management of bipolar disorders. However, its narrow therapeutic index and array of side effects, although well-documented, can be challenging to manage. Comparatively, the side effects of lithium that involve the ophthalmic structures are not as well established in the literature and only partially appreciated, which can potentially lead to noncompliance. In this article, an extensive literature review of lithium and its ophthalmic adverse effects were performed and comprehensively summarized. Based on the search, documented ophthalmic adverse effects of lithium include: exophthalmos; abnormal eye movements; ocular myasthenia gravis; papilledema; photophobia; and abnormal tear film, contributing to dry eye disease. Additional studies are anticipated to be helpful in expanding the current understanding of lithium and its adverse ophthalmic side effects and certainly warranted to fill the knowledge gap. Close interprofessional management between psychiatrists and ophthalmologists is expected to be beneficial in patient care. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.