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Personalized and precision medicine as informants for treatment management of bipolar disorder

Perugi, Giulioa; De Rossi, Pietrob,,c,,d; Fagiolini, Andreae; Girardi, Paolob; Maina, Giuseppef; Sani, Gabrieleb; Serretti, Alessandrog

International Clinical Psychopharmacology: July 2019 - Volume 34 - Issue 4 - p 189–205
doi: 10.1097/YIC.0000000000000260

DSM-5 diagnostic categories, defined by a set of psychopathological symptoms are heterogeneous conditions that may include different biological entities, with distinct etiopathogenesis, different courses and requiring different treatment management. For bipolar disorder the major evidences for this lack of validity are the long paths before a proper diagnosis, the inconsistence of treatment guidelines, the long phases of pharmacological adjustment and the low average of long-term treatment response rates. Personalized medicine for mental disorders aims to couple established clinical–pathological indexes with new molecular profiling to create diagnostic, prognostic and therapeutic strategies precisely tailored to each patient. Regarding bipolar disorder, the clinical history and presentation are still the most reliable markers in stratifying patients and guiding therapeutic management, despite the research goes to great lengths to develop new neuropsychological or biological markers that can reliably predict individual therapy effectiveness. We provide an overview of the advancements in personalized medicine in bipolar disorder, with particular attention to how psychopathology, age at onset, comorbidity, course and staging, genetic and epigenetic, imaging and biomarkers can influence treatment management and provide an integration to the conventional treatment guidelines. This approach may offer a new and rational path for the development of treatments for targeted subgroups of patients with bipolar disorder.

aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa

bNESMOS Department, School of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University – Rome, Rome

cDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome

dASL Rome 5, SPDC Ospedale SS. Gonfalone, Monterotondo, Rome

eDepartment of Molecular and developmental medicine, University of Siena, Siena

fDepartment of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin

gDepartment of Biomedical and NeuroMotor Sciences, University of Boulogne, Boulogne, Italy.

Received 31 October 2018 Accepted 7 March 2019

Correspondence to Professor Giulio Perugi, Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126, Pisa, Italy, Tel: +39 050 992543; fax: +39 050 21581; e-mail:

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