Secondary Logo

Institutional members access full text with Ovid®

A prospective study of adverse effects of antipsychotics in adolescents with schizophrenia during a 6-month follow-up

Ulloa, Rosa E.; Pérez-Garza, Rodolfo; Arce, Sofía; Bermúdez, Yvanna; Palacios, Lino

International Clinical Psychopharmacology: January 2019 - Volume 34 - Issue 1 - p 33–36
doi: 10.1097/YIC.0000000000000232

There is a paucity of follow-up studies of neurological, endocrine, and metabolic adverse effects of antipsychotics in adolescents from low-income and middle-income countries, who have a higher prevalence of obesity and overweight, and could present increased morbidity. A Mexican sample of 86 adolescents with schizophrenia was examined during a 6-month follow-up using the Simpson–Angus, abnormal involuntary movement and Barnes Akathisia rating scales, in addition to a side effects score sheet and other laboratory measures. Binary logistic regression models were used to identify specific variables as predictors of weight gain. Sleep difficulties, restlessness, drowsiness, changes in thyroid hormones, and a linear increase in weight gain were observed. A baseline positive and negative syndrome scale score greater than 97 predicted a 5 kg increase at month 3 (odds ratio: 4.52, 95% confidence interval: 1.5–13.2). The absence of a plateau in weight gain in the present study across the 6-month treatment period and its relationship with illness severity suggests that even longer follow-up time should be examined in future studies in these patient populations.

Child Psychiatric Hospital, Mexico City, Mexico

Correspondence to Rosa E. Ulloa, MD, PhD, SanBuenaventura, 86, 14080 Mexico City, Mexico Tel: +52 555 573 4844; e-mail:

Received March 26, 2018

Accepted June 5, 2018

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.