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The effect of methylphenidate treatment on psychopathic behavior of patients having attention-deficit hyperactivity disorder with and without oppositional defiant disorder

Golubchik, Pavela,b; Levy, Tomera,b; Weizman, Abrahamb,c,d

International Clinical Psychopharmacology: November 2018 - Volume 33 - Issue 6 - p 330–333
doi: 10.1097/YIC.0000000000000231
ORIGINAL ARTICLES
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To evaluate the effect of 3 months of methylphenidate (MPH) treatment on psychopathic behavior in children having attention-deficit hyperactivity disorder (ADHD) with and without comorbid oppositional defiant disorder (ODD). Twenty-seven children with Diagnostic and Statistical Manual of Mental Disorders, fifth ed., ADHD (13 female/14 male; aged 13.3±2.2 years old) were compared to an age/sex matched ADHD/ODD group (N=27, eight female/19 male; aged 11.8±1.9 years). The attention-deficit hyperactivity disorder rating scale (ADHD-RS) and the California Child Q-Set (CCQ) were used in both groups before MPH treatment (0.8–1.2 mg/kg/day) and 3 months thereafter. Significant reduction in the ADHD-RS scores was detected following MPH treatment in both the ADHD/ODD group and in the ADHD group (P<0.0011 and P=0.0012, respectively). Reduction in the CCQ scores was obtained in the ADHD/ODD group (P=0.0001) but not in in the ADHD group (P=0.18). A correlation was found between the reductions in the ADHD-RS and CCQ scores following MPH treatment in the ADHD/ODD group (Spearman’s r=0.43, P=0.024). MPH treatment in children with ADHD/ODD was associated with reduction in psychopathic scores, and the reduction correlated with a corresponding improvement in their ADHD severity.

aChild and Adolescent Outpatient Clinic, Geha Mental Health Center

bDepartment of Psychiatry, Sackler Faculty of Medicine, Tel Aviv University

cResearch Unit, Geha Mental Health Center

dFelsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel

Correspondence to Pavel Golubchik, MD, Child and Adolescent Outpatient Clinic, Geha Mental Health Center, PO Box 102, Petah Tikva 49100, Israel Tel: +972 3925 8270; fax: +972 3952 3598; e-mail: pavelgo@gmail.com

Received February 28, 2018

Accepted May 31, 2018

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