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Effectiveness of long-acting paliperidone palmitate in borderline personality disorder

Palomares, Nereaa; Montes, Anaa; Díaz-Marsá, Marinab,c; Carrasco, José L.b,c

International Clinical Psychopharmacology: November 2015 - Volume 30 - Issue 6 - p 338–341
doi: 10.1097/YIC.0000000000000095

The aim of the present study is to test the efficacy of palmitate paliperidone long-acting injection for patients with borderline personality disorder (BPD). A total of 16 patients with BPD were treated with intramuscular paliperidone palmitate (IMPP) over 12 weeks. Effectiveness measures included the CGI-BPD, HARS, MADRS, BIS-11, and STAXI-2. Functional improvement was assessed using the Global Assessment of Functioning scale. A list of adverse events was provided to clinicians and patients. Treatment with IMPP was associated with a significant average reduction of 1.6 (95% confidence interval: 1192–2008; P>0.01) in CGI-BPD scores and an average increase of psychosocial functioning as scored by the Global Assessment of Functioning scale of 13.3 (95% confidence interval: 8.35–18.31; P>0.01) was obtained. The treatment decreased impulsive-disruptive behaviors and improved general functioning. An acceptable tolerance was observed. The average weight gain was clinically irrelevant despite being statistically significant. No other relevant adverse side effects were reported, with the exception of galactorrhea, which required suspension of treatment in three patients. IMPP seems to be a well-tolerated alternative to other second-generation antipsychotics in the treatment of BPD. More controlled studies replicating these results should be proposed in the future.

aInstitute of Health Research of the Hospital Clínico San Carlos (IdISSC)

bDepartment of Psychiatry and Medical Psychology, Faculty of Medicine, Universidad Complutense

cBiomedical Research Networking Center, Mental Health (CIBERSAM), Hospital Gregorio Marañón, Madrid, Spain

Correspondence to Nerea Palomares, MS, Institute of Health Research from the Hospital Clínico San Carlos (IdISSC), Avenida Profesor Martín Lagos s/n, 28040, Madrid, Spain Tel: +34 91 330 3566; fax: +34 91330 3574; e-mail:

Received March 18, 2015

Accepted June 29, 2015

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